{"id":"W2015878973","doi":"10.1021/ac902813y","title":"Exploiting the Interaction of Metal Ions and Peptide Nucleic Acids−DNA Duplexes for the Detection of a Single Nucleotide Mismatch by Electrochemical Impedance Spectroscopy","year":2010,"lang":"en","type":"article","venue":"Analytical Chemistry","topic":"DNA and Nucleic Acid Chemistry","field":"Biochemistry, Genetics and Molecular Biology","cited_by":23,"is_retracted":false,"has_abstract":true,"ca_institutions":"Western University","funders":"Natural Sciences and Engineering Research Council of Canada; National Natural Science Foundation of China","keywords":"Chemistry; Dielectric spectroscopy; Nucleic acid; DNA; Nucleotide; Peptide; Ion; Peptide nucleic acid; Metal ions in aqueous solution; Electrochemistry; Metal; Combinatorial chemistry; Biochemistry; Electrode; Organic chemistry; Physical chemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001710536,0.0001707889,0.0001946724,0.000007901782,0.0001321258,0.00002248023,0.0002455699,0.0001683245,0.00002594986],"category_scores_gemma":[0.0004021948,0.0001220041,0.0001775407,0.00008838015,0.0005229462,0.000009708314,0.00009004478,0.000260765,4.198233e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000144208,"about_ca_system_score_gemma":0.00002756585,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001198844,"about_ca_topic_score_gemma":0.000007874945,"domain_scores_codex":[0.9990006,0.0000113075,0.0003054332,0.0002971891,0.0001326998,0.0002527318],"domain_scores_gemma":[0.999145,0.0001462407,0.0001722551,0.0003532037,0.0001103093,0.00007295472],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001231551,0.00007820274,0.0001797094,0.00008248028,0.0001006996,1.703001e-7,0.00003387463,5.264257e-7,0.9987099,0.000008325489,0.0002651419,0.000417836],"study_design_scores_gemma":[0.0002819199,0.00008458861,0.00005720562,0.00001620398,0.0001334527,0.00003404959,0.0004312466,0.0006635717,0.9949899,0.0001213211,0.003058858,0.0001276562],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969119,0.0002834009,0.001798556,0.000197567,0.00004129342,0.000103996,0.00002250447,0.00001050748,0.000630254],"genre_scores_gemma":[0.9989713,0.0000825444,0.000320614,0.0000400196,0.0002558482,0.00002120965,0.00003217098,0.00002404088,0.0002522307],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003719952,"threshold_uncertainty_score":0.4975183,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.007119215526706014,"score_gpt":0.2444311290945007,"score_spread":0.2373119135677947,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}