{"id":"W2015893941","doi":"10.1038/jid.2010.331","title":"A Flexible Multiplex Bead-Based Assay for Detecting Germline CDKN2A and CDK4 Variants in Melanoma-Prone Kindreds","year":2010,"lang":"en","type":"article","venue":"Journal of Investigative Dermatology","topic":"Cancer Genomics and Diagnostics","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Toronto","funders":"National Cancer Institute; Cancer Research UK","keywords":"Genotyping; CDKN2A; Multiplex; Biology; Context (archaeology); Genetics; Primer (cosmetics); Multiplex polymerase chain reaction; Genotype; Molecular biology; Polymerase chain reaction; Gene; Chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004368286,0.0001622938,0.0003393319,0.0001610213,0.00006781756,0.00002408063,0.0001593896,0.0002376861,0.000006143555],"category_scores_gemma":[0.001943965,0.0001547914,0.00008283035,0.00009155081,0.0002842955,0.00000896414,0.00005784188,0.0003103261,7.608742e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000189098,"about_ca_system_score_gemma":0.0003468235,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00002934952,"about_ca_topic_score_gemma":0.0005403581,"domain_scores_codex":[0.9988571,0.00008848559,0.0005008812,0.0002121107,0.00008070043,0.0002607699],"domain_scores_gemma":[0.9987539,0.0002539682,0.0004230902,0.0001558123,0.0002535923,0.0001596509],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001872653,0.00006185992,0.009958726,0.00003793302,0.0000518241,0.00004461282,0.0001233382,0.0001477697,0.9874529,0.000227368,0.0004733355,0.001233017],"study_design_scores_gemma":[0.002861933,0.0003777208,0.01524962,0.0000331399,0.00003285169,0.0006996265,0.00007391863,0.001840742,0.9728939,0.00158079,0.004164579,0.0001911926],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9922954,0.0004248602,0.005310093,0.001363171,0.0002970891,0.0002101237,0.00003668081,0.000003429275,0.00005914575],"genre_scores_gemma":[0.97764,0.00003273652,0.02121271,0.000815445,0.0002256777,0.00001855649,0.00002038497,0.00002243045,0.00001207895],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01590261,"threshold_uncertainty_score":0.6312212,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01717558633280467,"score_gpt":0.2697734143505597,"score_spread":0.252597828017755,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}