{"id":"W2015905063","doi":"10.1128/jb.187.19.6603-6611.2005","title":"FbpA-Dependent Biosynthesis of Trehalose Dimycolate Is Required for the Intrinsic Multidrug Resistance, Cell Wall Structure, and Colonial Morphology of <i>Mycobacterium smegmatis</i>","year":2005,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Mycobacterium research and diagnosis","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Mycobacterium smegmatis; Mycolic acid; Biology; Cell wall; Microbiology; Trehalose; Mycobacterium tuberculosis; Mutant; Mycobacterium; Peptidoglycan; Biochemistry; Bacteria; Gene; Tuberculosis; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008397322,0.0003421373,0.0002632408,0.0001287977,0.0001417145,0.0003426537,0.0001636024,0.0002348795,0.0005894029],"category_scores_gemma":[0.0001867172,0.0001500735,0.0002360059,0.0001140791,0.0001894833,0.000154188,0.0002134532,0.0003679061,0.0004183635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004094361,"about_ca_system_score_gemma":0.0002343067,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0018939,"about_ca_topic_score_gemma":0.001642443,"domain_scores_codex":[0.9998907,0.0000159746,0.0000142455,0.00002300329,0.00002953462,0.00002643712],"domain_scores_gemma":[0.9998848,0.00001638127,0.00003509467,0.00001790193,0.00001470438,0.00003110084],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003021841,0.000006816428,0.0001646558,0.00001073507,0.000001046898,0.000045007,0.000005771411,0.00001862055,0.9993369,0.0000312335,0.00001103913,0.0003378484],"study_design_scores_gemma":[0.000004578206,0.00005860004,0.00556063,0.000003400554,0.000005065332,0.0003745725,0.00001521858,0.000667606,0.9921986,0.00002369214,0.001084568,0.000003343012],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9947613,0.0009305186,0.00280985,0.0001089497,0.00001521356,0.00001807641,0.0004577171,0.0001072549,0.0007910705],"genre_scores_gemma":[0.9960867,0.0002730343,0.001872007,0.00002609981,0.000004963259,0.00001672747,0.000688194,0.00002787009,0.001004321],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0018939,"threshold_uncertainty_score":0.003765702,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135984995119756,"score_gpt":0.2682977106886639,"score_spread":0.2546992111766883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}