{"id":"W2015905063","doi":"10.1128/jb.187.19.6603-6611.2005","title":"FbpA-Dependent Biosynthesis of Trehalose Dimycolate Is Required for the Intrinsic Multidrug Resistance, Cell Wall Structure, and Colonial Morphology of <i>Mycobacterium smegmatis</i>","year":2005,"lang":"en","type":"article","venue":"Journal of Bacteriology","topic":"Mycobacterium research and diagnosis","field":"Medicine","cited_by":107,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Mycobacterium smegmatis; Mycolic acid; Biology; Cell wall; Microbiology; Trehalose; Mycobacterium tuberculosis; Mutant; Mycobacterium; Peptidoglycan; Biochemistry; Bacteria; Gene; Tuberculosis; Genetics","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006758081,0.0002520549,0.001138253,0.0003169896,0.00007464094,0.00001598919,0.0003011231,0.0002751394,0.0003373582],"category_scores_gemma":[0.0005390216,0.0001657147,0.0002825325,0.0001536724,0.0004233996,0.0001650759,0.0001091304,0.0003553658,0.000002624908],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00008960498,"about_ca_system_score_gemma":0.0002533353,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007214845,"about_ca_topic_score_gemma":0.0001458918,"domain_scores_codex":[0.9975568,0.0002391953,0.001235977,0.0002604301,0.0002759067,0.0004317093],"domain_scores_gemma":[0.9961159,0.001493433,0.001203159,0.0003919617,0.0005643512,0.0002312066],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.008751847,0.0003209481,0.0307146,0.0004725106,0.0004027905,0.00005071955,0.0006151942,0.000002752873,0.9504765,0.00005211845,0.003065353,0.005074668],"study_design_scores_gemma":[0.00822481,0.003382817,0.5204812,0.0002595632,0.0007292128,0.0007696541,0.00009915171,0.00006359161,0.4445328,0.0002320277,0.02097872,0.0002464371],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9921714,0.001315917,0.00005858036,0.005097083,0.000319827,0.000584286,0.0003876199,0.000006730718,0.00005854765],"genre_scores_gemma":[0.9924594,0.002531102,0.003807304,0.0005725036,0.0003981458,0.00001542592,0.00001244789,0.00003106719,0.0001726734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.5059437,"threshold_uncertainty_score":0.675765,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0135984995119756,"score_gpt":0.2682977106886639,"score_spread":0.2546992111766883,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}