{"id":"W2015913484","doi":"10.1021/tx100081p","title":"Evaluation of DNA Adducts, DNA and RNA Oxidative Lesions, and 3-Hydroxybenzo(<i>a</i>)pyrene as Biomarkers of DNA Damage in Lung Following Intravenous Injection of the Parent Compound in Rats","year":2010,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Agence Française de Sécurité Sanitaire de l'Environnement et du Travail","keywords":"DNA; Adduct; Pyrene; Chemistry; RNA; DNA damage; Molecular biology; Biochemistry; Biology; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.003002355,0.0001143635,0.0002733713,0.0002112711,0.00003354851,0.0000072936,0.0001803131,0.0002701616,0.00001213762],"category_scores_gemma":[0.001073738,0.0001006304,0.00004792484,0.0003440466,0.0004915332,0.000008266877,0.0003406123,0.0003619775,1.065092e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001029742,"about_ca_system_score_gemma":0.000380589,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003733968,"about_ca_topic_score_gemma":0.002381469,"domain_scores_codex":[0.9979368,0.0005842007,0.0004139,0.0003441491,0.0004366896,0.0002841922],"domain_scores_gemma":[0.9991557,0.0002050964,0.0001173115,0.0002667096,0.000189364,0.00006582609],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001748347,0.0003040009,0.01006064,0.00006879491,0.0000402267,0.000002996903,0.0002728269,0.00002430974,0.9856553,0.00007714667,0.00002955068,0.003289376],"study_design_scores_gemma":[0.00120604,0.0003021166,0.05436063,0.00006623789,0.00001684127,0.000006733885,0.0004291289,0.0008216122,0.9419513,0.0007434156,0.0000157043,0.00008027894],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9983299,0.000522172,0.000003373531,0.0002046592,0.00007876435,0.0006069992,0.00001581692,0.00000104132,0.0002372718],"genre_scores_gemma":[0.9996608,0.0001373095,0.00007952946,0.00001513528,0.00002219499,0.00004571393,0.00002592759,0.000009037578,0.000004368176],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.04429998,"threshold_uncertainty_score":0.410359,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0452127569610225,"score_gpt":0.3753662688901767,"score_spread":0.3301535119291542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}