{"id":"W2015913484","doi":"10.1021/tx100081p","title":"Evaluation of DNA Adducts, DNA and RNA Oxidative Lesions, and 3-Hydroxybenzo(<i>a</i>)pyrene as Biomarkers of DNA Damage in Lung Following Intravenous Injection of the Parent Compound in Rats","year":2010,"lang":"en","type":"article","venue":"Chemical Research in Toxicology","topic":"Carcinogens and Genotoxicity Assessment","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal","funders":"Agence Française de Sécurité Sanitaire de l'Environnement et du Travail","keywords":"DNA; Adduct; Pyrene; Chemistry; RNA; DNA damage; Molecular biology; Biochemistry; Biology; Organic chemistry; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000268448,0.0005603584,0.000369766,0.0005218548,0.0001709791,0.0002902519,0.0002162121,0.0006327291,0.0008002094],"category_scores_gemma":[0.0002791942,0.0003242686,0.000282047,0.0002696369,0.0003391008,0.0004912745,0.0001531307,0.0005123585,0.0002866471],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002854545,"about_ca_system_score_gemma":0.0003097919,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001157048,"about_ca_topic_score_gemma":0.00173537,"domain_scores_codex":[0.9997731,0.00004093718,0.0000100234,0.00007111676,0.00005072926,0.000054071],"domain_scores_gemma":[0.9995061,0.0000567465,0.0001928392,0.00003223521,0.00008764971,0.000124441],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007984408,0.00008749717,0.001724781,0.00001898625,0.00001151735,0.0000302923,0.00002148232,0.00008263368,0.9958178,0.00001148655,0.0000113399,0.001383727],"study_design_scores_gemma":[0.00002930356,0.005323748,0.01716393,0.000003366885,0.00004925174,0.0001099733,0.00004097561,0.0006286128,0.9763246,0.00002466196,0.0002934748,0.000008077969],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9969253,0.0006596425,0.001807909,0.00002427803,0.000009091517,0.00002850328,0.0001992374,0.00006682521,0.0002791339],"genre_scores_gemma":[0.9921645,0.001039839,0.003144883,0.00004905554,0.00001496386,0.00008318749,0.0005635907,0.00002530358,0.002914543],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001157048,"threshold_uncertainty_score":0.002677023,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0452127569610225,"score_gpt":0.3753662688901767,"score_spread":0.3301535119291542,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}