{"id":"W2015926136","doi":"10.1073/pnas.0803233105","title":"The ubiquitin ligase Nedd4-1 is dispensable for the regulation of PTEN stability and localization","year":2008,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":188,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network; SickKids Foundation; Hospital for Sick Children; Ontario Institute for Cancer Research; University of Toronto","funders":"","keywords":"PTEN; Ubiquitin ligase; NEDD4; Subcellular localization; Ubiquitin; DNA ligase; Biology; Cell biology; Cytoplasm; PI3K/AKT/mTOR pathway; Cancer research; Molecular biology; Gene; Signal transduction; Biochemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002728741,0.0002587102,0.0003501162,0.0003028931,0.0001936113,0.0006254849,0.0003674095,0.000212243,0.0007195447],"category_scores_gemma":[0.0002641336,0.0002514391,0.0001944212,0.0001672477,0.0003826627,0.0002743738,0.0003598965,0.0003316028,0.0002846865],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003945805,"about_ca_system_score_gemma":0.0002547316,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003686703,"about_ca_topic_score_gemma":0.0006144146,"domain_scores_codex":[0.9997874,0.0000347181,0.00002650206,0.00005109697,0.00006353331,0.00003687691],"domain_scores_gemma":[0.9997839,0.00003835632,0.0000691879,0.00003399575,0.00001979682,0.00005464113],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001096703,0.00001017567,0.0004772473,0.00001963497,0.000005193054,0.0001247313,0.00000497447,0.00005456303,0.9979475,0.00017178,0.0000154829,0.001058896],"study_design_scores_gemma":[0.00002605359,0.00009707068,0.009069883,0.000004938893,0.00001914107,0.001361674,0.00002274306,0.001409106,0.9852386,0.0001559996,0.002588756,0.000005966431],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950642,0.001549051,0.002212852,0.00007035875,0.00001505239,0.00000488901,0.0001639185,0.00003321693,0.000886512],"genre_scores_gemma":[0.9967479,0.0004462276,0.001142123,0.00001927404,0.000003105047,0.000005315872,0.0004055135,0.00001490765,0.001215694],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007195447,"threshold_uncertainty_score":0.00286293,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0490315589677091,"score_gpt":0.289555580182684,"score_spread":0.2405240212149748,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}