{"id":"W2015939628","doi":"10.1074/jbc.m313852200","title":"Serpin Mechanism of Hepatitis C Virus Nonstructural 3 (NS3) Protease Inhibition","year":2004,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Hepatitis C virus research","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"National Institute of General Medical Sciences","keywords":"Serpin; NS3; Protease; NS2-3 protease; Serine protease; Biochemistry; Proteolysis; Proteases; Chymotrypsin; Hepatitis C virus; Enzyme; Biology; MASP1; Serine Proteinase Inhibitors; Chemistry; Virus; Trypsin; Virology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001746968,0.0005256365,0.0003003159,0.000189912,0.0001183866,0.0002853906,0.0003431546,0.0002477449,0.0007038785],"category_scores_gemma":[0.00009202048,0.0001206466,0.0003565311,0.0000655903,0.0002308582,0.0001992456,0.0001776994,0.0004662661,0.0002759921],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002313981,"about_ca_system_score_gemma":0.0001454441,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000177288,"about_ca_topic_score_gemma":0.0001790725,"domain_scores_codex":[0.9998959,0.00001917639,0.000006665059,0.00002021174,0.00002977499,0.00002825019],"domain_scores_gemma":[0.9999571,0.000007793195,0.0000135388,0.000003794161,0.000008321319,0.000009436857],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001527477,0.00004992622,0.0001926121,0.0001284411,0.00002301613,0.0001405168,0.00001151885,0.0005818995,0.988645,0.001003344,0.0001841375,0.008886986],"study_design_scores_gemma":[0.00003421522,0.0006319565,0.0009261552,0.000007037725,0.00001906926,0.000524984,0.000004568743,0.002693296,0.9921572,0.0001399982,0.002855504,0.000006102219],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9231024,0.02165001,0.03697664,0.0004638383,0.0001974684,0.0003636522,0.0004536786,0.0006810122,0.01611131],"genre_scores_gemma":[0.9911605,0.003585239,0.002998001,0.0001152262,0.00002161461,0.00005998222,0.00009182798,0.00001223912,0.001955366],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007038785,"threshold_uncertainty_score":0.002354681,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03174959283296173,"score_gpt":0.3008876513373013,"score_spread":0.2691380585043395,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}