{"id":"W2015958792","doi":"10.1016/j.cellsig.2011.09.027","title":"Structural basis for specificity of TGFβ family receptor small molecule inhibitors","year":2011,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Institutes of Health Research; Leids Universitair Medisch Centrum; Wellcome Trust","keywords":"Activin receptor; Receptor; Chemistry; TGF beta signaling pathway; TGF beta receptor 2; Signal transduction; Cell biology; Biochemistry; Molecular biology; Biology; Growth factor; TGF alpha","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001887162,0.000231431,0.0002293087,0.00006241197,0.00009592631,0.00001578354,0.0003312792,0.0001816408,0.0001135147],"category_scores_gemma":[0.00007362993,0.0002376245,0.0002526419,0.00008648013,0.0001054645,0.000004554349,0.00008755628,0.00008255981,0.000008011973],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001667753,"about_ca_system_score_gemma":0.0001004044,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003825019,"about_ca_topic_score_gemma":0.000007655443,"domain_scores_codex":[0.9986275,0.00005619003,0.0004005074,0.0004499853,0.0001444413,0.00032141],"domain_scores_gemma":[0.9991269,0.0000257681,0.0001965588,0.0003387047,0.0001851181,0.0001270215],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001559231,0.00005242438,0.000919049,0.00007114609,0.00007778616,0.000002316308,0.0001749972,0.00009907186,0.9975045,0.00007139243,0.0002399102,0.0006314322],"study_design_scores_gemma":[0.0003456697,0.0002128185,0.000248832,0.00004091834,0.0000461849,7.298394e-7,0.0002258399,0.0001162946,0.9966401,0.00006807355,0.001772957,0.0002816123],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9758819,0.002021436,0.02097937,0.000003503977,0.0002759161,0.0003160022,0.00005513992,0.00002639628,0.0004403465],"genre_scores_gemma":[0.98906,0.00001750377,0.01011241,0.00004222806,0.0003810361,0.00002827449,0.0001718522,0.00005561288,0.0001310656],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01317812,"threshold_uncertainty_score":0.9690048,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0366036804008458,"score_gpt":0.2230293664655849,"score_spread":0.1864256860647391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}