{"id":"W2015958792","doi":"10.1016/j.cellsig.2011.09.027","title":"Structural basis for specificity of TGFβ family receptor small molecule inhibitors","year":2011,"lang":"en","type":"article","venue":"Cellular Signalling","topic":"TGF-β signaling in diseases","field":"Biochemistry, Genetics and Molecular Biology","cited_by":58,"is_retracted":false,"has_abstract":false,"ca_institutions":"Canada Research Chairs; University of Toronto; Mount Sinai Hospital; Lunenfeld-Tanenbaum Research Institute","funders":"Canadian Institutes of Health Research; Leids Universitair Medisch Centrum; Wellcome Trust","keywords":"Activin receptor; Receptor; Chemistry; TGF beta signaling pathway; TGF beta receptor 2; Signal transduction; Cell biology; Biochemistry; Molecular biology; Biology; Growth factor; TGF alpha","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003082461,0.0004550308,0.0004160164,0.0002080782,0.0002616544,0.0005608019,0.0006432962,0.0004090986,0.003196739],"category_scores_gemma":[0.0003621577,0.0002845692,0.0003299312,0.00009041143,0.0003112262,0.0003181506,0.0002452317,0.0007534106,0.001070533],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005564452,"about_ca_system_score_gemma":0.0003156183,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003912469,"about_ca_topic_score_gemma":0.0004344391,"domain_scores_codex":[0.9998185,0.00003889724,0.00001427447,0.00003725467,0.00004349435,0.00004751739],"domain_scores_gemma":[0.9998642,0.00004106745,0.00003000121,0.00001146045,0.00002439356,0.00002877099],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0004615139,0.00008215289,0.0002571672,0.00009753533,0.00003561539,0.0004966109,0.00003371843,0.003185957,0.9704823,0.01660854,0.0007326719,0.007526176],"study_design_scores_gemma":[0.0002171312,0.0004670671,0.0009038652,0.00001450898,0.0000487781,0.001385007,0.00002759427,0.01161612,0.9665807,0.002960334,0.01575419,0.00002478731],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8932369,0.007867375,0.05965004,0.002095454,0.0004276086,0.0003305885,0.0006201285,0.0008110292,0.0349609],"genre_scores_gemma":[0.9887404,0.001426847,0.005448298,0.0004754338,0.0000367586,0.0000686436,0.0002416049,0.00003434644,0.003527683],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003196739,"threshold_uncertainty_score":0.01069421,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0366036804008458,"score_gpt":0.2230293664655849,"score_spread":0.1864256860647391,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}