{"id":"W2015961921","doi":"10.1016/s0014-5793(01)03292-6","title":"Interaction domains: from simple binding events to complex cellular behavior","year":2001,"lang":"en","type":"review","venue":"FEBS Letters","topic":"Ubiquitin and proteasome pathways","field":"Biochemistry, Genetics and Molecular Biology","cited_by":158,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto; Mount Sinai Hospital","funders":"","keywords":"Simple (philosophy); Protein–protein interaction; Computational biology; Signaling proteins; Signal transduction; Biological system; Biology; Cell biology; Chemistry; Computer science","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004751631,0.000843618,0.001289873,0.0009338813,0.0003932165,0.001381583,0.001283823,0.001390055,0.001775054],"category_scores_gemma":[0.0004080215,0.0003485495,0.0002122317,0.001121397,0.001387662,0.002024833,0.0008457341,0.001499755,0.003722633],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008494869,"about_ca_system_score_gemma":0.0004610404,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005387831,"about_ca_topic_score_gemma":0.0005627901,"domain_scores_codex":[0.9998129,0.00003487256,0.00001810697,0.000043779,0.00006681169,0.00002344931],"domain_scores_gemma":[0.9998401,0.00006710188,0.00002619595,0.00001193597,0.00002995303,0.00002468159],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0001437595,0.00004230046,0.0004157132,0.00612302,0.00005916635,0.0009548106,0.0002034062,0.0009014924,0.02491735,0.02875592,0.02432948,0.9131535],"study_design_scores_gemma":[0.00001966773,0.00005228618,0.0006515349,0.0006195419,0.00002862184,0.003524419,0.00008881024,0.0001811083,0.004879996,0.009101545,0.9808319,0.000020626],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.001371739,0.9910797,0.001648384,0.0005872056,0.0003631637,0.000008165599,0.00002490522,0.00004528268,0.004871507],"genre_scores_gemma":[0.009266592,0.9836543,0.001280877,0.0008253951,0.000365898,0.00002472638,0.00006772365,0.000008812026,0.004505679],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.001775054,"threshold_uncertainty_score":0.006163478,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06001053549695792,"score_gpt":0.3277880646031736,"score_spread":0.2677775291062157,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}