{"id":"W2015974289","doi":"10.1038/mt.2010.30","title":"Processing of Tumor Antigen Differentially Impacts the Development of Helper and Effector CD4+ T-cell Responses","year":2010,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Effector; Cytotoxic T cell; Biology; Immunogenicity; Antigen; T cell; Streptamer; CD8; T helper cell; Cell biology; Immunology; Interleukin 21; Immune system; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004548604,0.0001901052,0.0002926165,0.00009847649,0.0001786203,0.00001652036,0.0002611597,0.0001230337,0.000138402],"category_scores_gemma":[0.00005232756,0.0001196782,0.00008762105,0.0001039693,0.0003493365,0.0000440256,0.00004795281,0.0002313504,0.00001170055],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000005418919,"about_ca_system_score_gemma":0.0001956497,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001801542,"about_ca_topic_score_gemma":0.000006001321,"domain_scores_codex":[0.9988368,0.0003407035,0.0003451453,0.0001774381,0.00005805012,0.0002418966],"domain_scores_gemma":[0.9992191,0.0001633637,0.0002104717,0.0003120257,0.00008151985,0.00001351224],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001975268,0.0001645809,0.001422997,0.00003513323,0.0001527881,0.000001776244,0.002319221,1.474653e-7,0.9645984,0.00002005493,0.00000966577,0.02929996],"study_design_scores_gemma":[0.001535081,0.0002400533,0.06311418,0.00004227536,0.00001083905,0.0000226134,0.0001085374,6.923227e-7,0.9291674,0.00001768286,0.005609939,0.0001306556],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796336,0.0193861,0.0003378994,0.00006545171,0.0001734861,0.0003156388,0.000006655437,0.00001837422,0.00006275933],"genre_scores_gemma":[0.9989478,0.0002086983,0.00042692,0.0001068338,0.000005958825,0.00001710394,0.00000963636,0.0000252656,0.0002517565],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06169118,"threshold_uncertainty_score":0.4880337,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008278541375862513,"score_gpt":0.2413600701090108,"score_spread":0.2330815287331483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}