{"id":"W2015974289","doi":"10.1038/mt.2010.30","title":"Processing of Tumor Antigen Differentially Impacts the Development of Helper and Effector CD4+ T-cell Responses","year":2010,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Immunotherapy and Immune Responses","field":"Immunology and Microbiology","cited_by":4,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Canadian Institutes of Health Research","keywords":"Effector; Cytotoxic T cell; Biology; Immunogenicity; Antigen; T cell; Streptamer; CD8; T helper cell; Cell biology; Immunology; Interleukin 21; Immune system; In vitro; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002101845,0.0002908117,0.0002419374,0.0001708423,0.00008467891,0.0005107321,0.0001740408,0.0003815623,0.0009768463],"category_scores_gemma":[0.0002306819,0.0002079652,0.0002101679,0.0001088878,0.0001856375,0.0002869454,0.0001984643,0.0006578925,0.0003173653],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002230664,"about_ca_system_score_gemma":0.0002255288,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002310978,"about_ca_topic_score_gemma":0.0003472498,"domain_scores_codex":[0.9996951,0.00005156088,0.00002431803,0.00005366169,0.00004990907,0.0001255537],"domain_scores_gemma":[0.9998486,0.00004236153,0.00002574016,0.00001637785,0.00001660269,0.0000502717],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001414329,0.00003073764,0.0004138851,0.00001600549,0.000002375713,0.00002240089,0.00000757437,0.00007325013,0.9983875,0.00004069164,0.0000109142,0.0008532755],"study_design_scores_gemma":[0.00003663039,0.0008546848,0.01242436,0.000007062513,0.00003256337,0.0002692709,0.00007404052,0.001530692,0.9834592,0.0001290818,0.001175296,0.000007143372],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9981931,0.0003315359,0.0005842334,0.00003106782,0.000008453277,0.00001184691,0.00006470671,0.00001490479,0.0007600858],"genre_scores_gemma":[0.9980604,0.0002271203,0.0007454022,0.00003786447,0.000004533605,0.00001836353,0.0001317074,0.00001022917,0.0007644577],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009768463,"threshold_uncertainty_score":0.003267944,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008278541375862513,"score_gpt":0.2413600701090108,"score_spread":0.2330815287331483,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}