{"id":"W2015988724","doi":"10.1073/pnas.0406874102","title":"Convergent signaling by acidosis and receptor activator of NF-κB ligand (RANKL) on the calcium/calcineurin/NFAT pathway in osteoclasts","year":2005,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":159,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canadian Institutes of Health Research; Western University","funders":"","keywords":"NFAT; RANKL; Calcineurin; Endocrinology; Internal medicine; Osteoclast; Acidosis; Chemistry; Extracellular; Cell biology; Biology; Activator (genetics); Receptor; Medicine; Transplantation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002952861,0.0004069095,0.0003990272,0.0003099763,0.0002773408,0.0004024954,0.0001732427,0.0002815674,0.0007266412],"category_scores_gemma":[0.0001285002,0.0001586311,0.0005386983,0.0002146234,0.0003535529,0.0003128937,0.000563012,0.0005670608,0.0001917892],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003120602,"about_ca_system_score_gemma":0.0003481136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005916288,"about_ca_topic_score_gemma":0.0009467788,"domain_scores_codex":[0.9997151,0.00004557341,0.00002590338,0.00004830647,0.00009621585,0.0000689649],"domain_scores_gemma":[0.9998994,0.000009412189,0.0000298407,0.000008946909,0.00002186272,0.00003063629],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.0005203452,0.00002594652,0.0008030506,0.0002077697,0.0000171871,0.0003793109,0.00007693208,0.00009153999,0.9951577,0.0002510789,0.00004903784,0.002420115],"study_design_scores_gemma":[0.0004111762,0.001969466,0.09864608,0.0001099831,0.0002497546,0.003623623,0.0006005002,0.003001372,0.8773989,0.001382373,0.01254917,0.00005761402],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9641775,0.02594654,0.006047782,0.0003221114,0.00008902941,0.00009034514,0.0005579025,0.000101277,0.002667442],"genre_scores_gemma":[0.9881555,0.006590646,0.0026598,0.0001125182,0.0000437594,0.00008168637,0.0003505213,0.000008283457,0.00199734],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007266412,"threshold_uncertainty_score":0.002430856,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03059698748445133,"score_gpt":0.2819943254548802,"score_spread":0.2513973379704289,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}