{"id":"W2016005076","doi":"10.1016/j.molcel.2014.05.012","title":"The Calcineurin Signaling Network Evolves via Conserved Kinase-Phosphatase Modules that Transcend Substrate Identity","year":2014,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Calcineurin; Biology; Phosphatase; Kinase; Dephosphorylation; Cell biology; Phosphorylation; Biochemistry; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0006071276,0.0003184698,0.0002031196,0.00001883444,0.0003365838,0.0001420007,0.0006045517,0.0001665659,0.00002400633],"category_scores_gemma":[0.00007638337,0.000275916,0.0002686728,0.0001282473,0.0002050544,0.000009412912,0.0001067369,0.0001736974,0.00003200522],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001414806,"about_ca_system_score_gemma":0.00005277228,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00005882717,"about_ca_topic_score_gemma":0.00006585701,"domain_scores_codex":[0.9979086,0.0003355461,0.0002968239,0.0005703525,0.0003172723,0.0005714137],"domain_scores_gemma":[0.9986256,0.00006411176,0.0001394488,0.0008681387,0.00008591152,0.0002168288],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001547572,0.00008997036,0.00289774,0.00005519654,0.00007365176,0.00006876582,0.00001961884,0.008541451,0.9857051,0.0004109161,0.001287845,0.000694973],"study_design_scores_gemma":[0.0007405197,0.000118076,0.0006905567,0.0000242756,0.00008374832,0.000005203249,0.00001967639,0.001231895,0.9888283,0.001215885,0.006686729,0.0003551146],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9292672,0.009494127,0.06002286,0.000118198,0.0003340734,0.0002851784,0.00003453993,0.00004640686,0.0003974635],"genre_scores_gemma":[0.9978525,0.0000779795,0.0008088538,0.0005819766,0.0002175657,0.00003927779,0.0002153686,0.00006548272,0.0001410145],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.06858533,"threshold_uncertainty_score":0.9999693,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01105481656084513,"score_gpt":0.2237208638144579,"score_spread":0.2126660472536127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}