{"id":"W2016005076","doi":"10.1016/j.molcel.2014.05.012","title":"The Calcineurin Signaling Network Evolves via Conserved Kinase-Phosphatase Modules that Transcend Substrate Identity","year":2014,"lang":"en","type":"article","venue":"Molecular Cell","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":118,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval","funders":"National Institute of General Medical Sciences; Canadian Institutes of Health Research; National Institutes of Health; Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung; National Science Foundation","keywords":"Calcineurin; Biology; Phosphatase; Kinase; Dephosphorylation; Cell biology; Phosphorylation; Biochemistry; Computational biology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003101273,0.0002533863,0.000261431,0.0002832991,0.0003798434,0.001305213,0.0005737834,0.0004465926,0.0006803569],"category_scores_gemma":[0.000536224,0.0002403015,0.0002173493,0.0002371516,0.0006121753,0.001116862,0.0006520511,0.0008729995,0.0005062826],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005635749,"about_ca_system_score_gemma":0.0004222603,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004453275,"about_ca_topic_score_gemma":0.0005339119,"domain_scores_codex":[0.9998233,0.00002277758,0.000009722409,0.00005327931,0.00005431259,0.00003655595],"domain_scores_gemma":[0.9997776,0.00002706675,0.00005364084,0.00004748827,0.00004360287,0.00005063563],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001540453,0.0000302655,0.002719986,0.00003806454,0.0000240101,0.000389737,0.0001234183,0.001372431,0.9578357,0.02188611,0.0001636603,0.01526264],"study_design_scores_gemma":[0.00007245723,0.0003091588,0.03521628,0.0000422705,0.000103851,0.003384967,0.0002445943,0.03324987,0.8892391,0.02092257,0.01715001,0.00006480225],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9651447,0.001287687,0.02644468,0.0003378833,0.00005258019,0.00002091588,0.00007154814,0.0002581472,0.006381963],"genre_scores_gemma":[0.9933593,0.0004963772,0.004774699,0.00006649385,0.00001312986,0.000007191951,0.00008792108,0.00002724315,0.001167701],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001305213,"threshold_uncertainty_score":0.004089057,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01105481656084513,"score_gpt":0.2237208638144579,"score_spread":0.2126660472536127,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}