{"id":"W2016044476","doi":"10.3791/2831","title":"Detection of Neuritic Plaques in Alzheimer's Disease Mouse Model","year":2011,"lang":"en","type":"article","venue":"Journal of Visualized Experiments","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":65,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Canadian Institutes of Health Research; Michael Smith Health Research BC","keywords":"Senile plaques; Pathogenesis; Pathology; Alzheimer's disease; Amyloid precursor protein; Genetically modified mouse; Neurofibrillary tangle; Amyloid (mycology); BACE1-AS; Biology; Medicine; Transgene; Disease; Gene; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001130399,0.002588175,0.001422568,0.002675845,0.00100345,0.0006604682,0.001609336,0.001766646,0.005585225],"category_scores_gemma":[0.0003349964,0.0008973347,0.001007126,0.0008129579,0.0007402569,0.0009532456,0.000856744,0.00355818,0.003769016],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0007793542,"about_ca_system_score_gemma":0.0005680456,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009197083,"about_ca_topic_score_gemma":0.001623543,"domain_scores_codex":[0.9989136,0.0001253212,0.0001699789,0.0003397258,0.0003118928,0.0001395656],"domain_scores_gemma":[0.999482,0.00005400692,0.0001172537,0.00009572258,0.0001174965,0.0001336543],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002857515,0.0005313797,0.0002227652,0.0002079178,0.00003553348,0.0002390959,0.0001124564,0.00006335301,0.9945987,0.0006387955,0.0007639081,0.002300235],"study_design_scores_gemma":[0.0002158514,0.001642008,0.003394482,0.0001263785,0.0002178919,0.002034051,0.00008787106,0.001615248,0.9624628,0.0007851223,0.02736272,0.0000556158],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.7430771,0.02215412,0.1782436,0.002711457,0.002403416,0.004079406,0.01634769,0.007449019,0.02353431],"genre_scores_gemma":[0.5858405,0.03404266,0.2385661,0.001487354,0.0004604881,0.01199553,0.02543207,0.00130754,0.1008678],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005585225,"threshold_uncertainty_score":0.01868445,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08876107883736926,"score_gpt":0.4363599519508107,"score_spread":0.3475988731134415,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}