{"id":"W2016111743","doi":"10.1016/j.clinthera.2014.10.002","title":"Pharmacokinetics and Pharmacodynamics of Setrobuvir, an Orally Administered Hepatitis C Virus Non-Nucleoside Analogue Inhibitor","year":2014,"lang":"en","type":"article","venue":"Clinical Therapeutics","topic":"Hepatitis C virus research","field":"Medicine","cited_by":10,"is_retracted":false,"has_abstract":false,"ca_institutions":"","funders":"Medical Research Council Canada","keywords":"Medicine; Pharmacokinetics; Cmax; Pharmacodynamics; Dosing; Placebo; Pharmacology; Gastroenterology; Oral administration; Hepatitis C virus; Hepatitis C; Internal medicine; Immunology; Virus","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004166561,0.0003404498,0.0006519809,0.0002025338,0.0002307611,0.0008678391,0.0002606995,0.0004619972,0.00114507],"category_scores_gemma":[0.001188397,0.0003493423,0.0003850211,0.0002546228,0.000506131,0.0005615205,0.0001107391,0.001566245,0.0003348087],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006157106,"about_ca_system_score_gemma":0.0007322605,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001759356,"about_ca_topic_score_gemma":0.001687761,"domain_scores_codex":[0.999631,0.0001938746,0.00001466929,0.00004500931,0.00007085524,0.00004449164],"domain_scores_gemma":[0.9996955,0.0001308313,0.00005949749,0.00003077005,0.00001968814,0.0000637076],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.2254843,0.005290951,0.01599047,0.0003870076,0.0008521905,0.0011459,0.0007444941,0.01415041,0.497674,0.002226822,0.004174954,0.2318785],"study_design_scores_gemma":[0.01656242,0.257026,0.2329694,0.00009988423,0.002055229,0.008084835,0.0007608818,0.0711935,0.3857928,0.001656047,0.02345049,0.0003485202],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9940393,0.001964495,0.001487691,0.0001506247,0.0000441513,0.00005800241,0.0002869077,0.00009803102,0.001870798],"genre_scores_gemma":[0.9978362,0.0004499682,0.0005864084,0.00007096396,0.0000331275,0.00002569218,0.000222727,0.00002774169,0.0007472199],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001759356,"threshold_uncertainty_score":0.004467368,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1035620004401135,"score_gpt":0.4479772523695192,"score_spread":0.3444152519294056,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}