{"id":"W2016126410","doi":"10.1093/nar/gkn1070","title":"A self-cleaving DNA enzyme modified with amines, guanidines and imidazoles operates independently of divalent metal cations (M 2+ )","year":2009,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Deoxyribozyme; Cationic polymerization; Nucleic acid; Catalysis; Phosphodiester bond; DNA; Imidazole; Cleavage (geology); Oligonucleotide; Combinatorial chemistry; Stereochemistry; Amine gas treating; Chemistry; Biology; Biochemistry; Organic chemistry; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003795688,0.000152342,0.0001993248,0.0001580728,0.0001877433,0.00004771688,0.0002129181,0.0001308042,0.000002145076],"category_scores_gemma":[0.00009256783,0.0001137087,0.0000511976,0.0003033182,0.0002171437,0.00001224012,0.0001388129,0.0001673908,9.064611e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002008467,"about_ca_system_score_gemma":0.00005220438,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00003798836,"about_ca_topic_score_gemma":0.00004782415,"domain_scores_codex":[0.9986371,0.0001083859,0.0002092666,0.0003811481,0.0003657965,0.0002982717],"domain_scores_gemma":[0.999067,0.00002271809,0.00006032758,0.0003579428,0.0004043305,0.00008768546],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000089108,0.0001474892,0.001071315,0.00002149772,0.00007722402,0.000004639297,0.0001106289,0.00001332785,0.9953036,0.0002695799,0.0001058665,0.002785771],"study_design_scores_gemma":[0.0003195529,0.0005604429,0.005077635,0.00003302154,0.00003542307,0.0000277685,0.000376674,0.0003791503,0.9922979,0.0001358508,0.000586621,0.0001699695],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9978965,0.0005709608,0.0003100458,0.000371899,0.000006760516,0.0001990042,0.00001209367,0.00003782968,0.0005948865],"genre_scores_gemma":[0.9919749,0.000649176,0.007018621,0.0000347215,0.00005691072,0.00000869872,0.00004225126,0.00001641243,0.0001983414],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006708575,"threshold_uncertainty_score":0.4636906,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02489634736628667,"score_gpt":0.323616082448087,"score_spread":0.2987197350818004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}