{"id":"W2016126410","doi":"10.1093/nar/gkn1070","title":"A self-cleaving DNA enzyme modified with amines, guanidines and imidazoles operates independently of divalent metal cations (M 2+ )","year":2009,"lang":"en","type":"article","venue":"Nucleic Acids Research","topic":"Advanced biosensing and bioanalysis techniques","field":"Biochemistry, Genetics and Molecular Biology","cited_by":133,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"Schweizerischer Nationalfonds zur Förderung der Wissenschaftlichen Forschung","keywords":"Deoxyribozyme; Cationic polymerization; Nucleic acid; Catalysis; Phosphodiester bond; DNA; Imidazole; Cleavage (geology); Oligonucleotide; Combinatorial chemistry; Stereochemistry; Amine gas treating; Chemistry; Biology; Biochemistry; Organic chemistry; RNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001892621,0.0004358817,0.0003498514,0.0001347515,0.0001219918,0.0002934993,0.0003395359,0.0005102023,0.0004875217],"category_scores_gemma":[0.0003406948,0.000199511,0.0001858226,0.0001588077,0.0003058066,0.0002661958,0.0001896982,0.0003926082,0.0003415641],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002128841,"about_ca_system_score_gemma":0.0001551453,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001506414,"about_ca_topic_score_gemma":0.0002810685,"domain_scores_codex":[0.9998159,0.00002356735,0.0000105783,0.00008743014,0.00004344888,0.00001904514],"domain_scores_gemma":[0.9997924,0.00004999969,0.00007240479,0.00002323541,0.0000210117,0.00004090281],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001980406,0.000006058877,0.0001557013,0.00002265678,0.000003349759,0.00002328089,0.000006275643,0.00003260426,0.9985788,0.00006651092,0.000007375309,0.001077589],"study_design_scores_gemma":[0.000003668637,0.0001151441,0.0008180357,0.000001921179,0.00000634293,0.0002835484,0.000005225504,0.0003384882,0.9972928,0.00002504169,0.001107203,0.000002562648],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9617562,0.002812877,0.03281853,0.0001232853,0.00007299579,0.0001024204,0.000149104,0.0001436233,0.002020862],"genre_scores_gemma":[0.961106,0.0009858322,0.03422787,0.0000536617,0.00001704899,0.00003288311,0.000175883,0.00002482794,0.003375968],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0005102023,"threshold_uncertainty_score":0.001630962,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02489634736628667,"score_gpt":0.323616082448087,"score_spread":0.2987197350818004,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}