{"id":"W2016127324","doi":"10.1371/journal.pgen.1003274","title":"Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity","year":2013,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":252,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; University of California, San Diego; University of Toronto; Institut National de la Santé et de la Recherche Médicale; National Institute of Diabetes and Digestive and Kidney Diseases; Oregon State University; National Institutes of Health; Vanderbilt University","keywords":"Biology; PDX1; Transcription factor; Enteroendocrine cell; Endocrine system; Cell biology; Beta cell; Endocrinology; Internal medicine; Genetics; Hormone; Gene; Insulin; Islet; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000299819,0.0001900731,0.0004591844,0.00006478334,0.0001485545,0.0001382867,0.000085515,0.000123287,0.0001110606],"category_scores_gemma":[0.0002861745,0.0001768383,0.00008158579,0.000131452,0.000112103,0.0001939225,0.00006247329,0.0001111603,0.0000301771],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004951573,"about_ca_system_score_gemma":0.00006781845,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001699386,"about_ca_topic_score_gemma":0.000003773386,"domain_scores_codex":[0.998571,0.0000518774,0.0003575725,0.0003130009,0.0002567844,0.0004497021],"domain_scores_gemma":[0.9986388,0.0003884488,0.000135412,0.000374487,0.0001868854,0.000275939],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002588882,0.0003126276,0.1772691,0.0006928322,0.000558937,0.00001341138,0.0005944542,0.0003284509,0.8012579,0.001337247,0.01327972,0.004096388],"study_design_scores_gemma":[0.02350073,0.002883675,0.1973889,0.001345704,0.005473141,0.00007542765,0.002860515,0.2768278,0.4636029,0.01975872,0.004507155,0.00177542],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892924,0.004251747,0.002919491,0.0003513508,0.0001668101,0.001156272,0.00001024785,0.00008824062,0.001763405],"genre_scores_gemma":[0.9788038,0.0001678396,0.01809875,0.001130097,0.0006464833,0.0001804905,0.00004220281,0.00004656653,0.0008838143],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.337655,"threshold_uncertainty_score":0.7211255,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02247958299456598,"score_gpt":0.2397634969448545,"score_spread":0.2172839139502885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}