{"id":"W2016127324","doi":"10.1371/journal.pgen.1003274","title":"Nkx6.1 Controls a Gene Regulatory Network Required for Establishing and Maintaining Pancreatic Beta Cell Identity","year":2013,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Pancreatic function and diabetes","field":"Medicine","cited_by":252,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"National Institute of General Medical Sciences; University of California, San Diego; University of Toronto; Institut National de la Santé et de la Recherche Médicale; National Institute of Diabetes and Digestive and Kidney Diseases; Oregon State University; National Institutes of Health; Vanderbilt University","keywords":"Biology; PDX1; Transcription factor; Enteroendocrine cell; Endocrine system; Cell biology; Beta cell; Endocrinology; Internal medicine; Genetics; Hormone; Gene; Insulin; Islet; Medicine","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00009145885,0.0002394443,0.000187432,0.0001476052,0.0001715491,0.0003187204,0.0002484508,0.0001596143,0.001347007],"category_scores_gemma":[0.0001605821,0.0001592143,0.0001250024,0.0000613219,0.0002277919,0.0002356909,0.0003474455,0.0003789033,0.0005547519],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002440764,"about_ca_system_score_gemma":0.0001432148,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000372464,"about_ca_topic_score_gemma":0.0006429492,"domain_scores_codex":[0.9998673,0.000014478,0.00001133516,0.00004488602,0.00003565347,0.00002630409],"domain_scores_gemma":[0.9998713,0.00001340826,0.00005410169,0.000009511959,0.00001363206,0.00003808388],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005496995,0.000007072448,0.0005848819,0.00001695133,0.000001458887,0.00004651126,0.00001917013,0.00009109303,0.9976403,0.0001563477,0.00002526493,0.001356107],"study_design_scores_gemma":[0.00003865196,0.0001312181,0.04688335,0.00001974188,0.00001748338,0.0007652796,0.0000953932,0.004816805,0.9408246,0.0004849806,0.005911702,0.00001068161],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9902563,0.001331953,0.004839478,0.0001017486,0.00003951714,0.00001411129,0.000284692,0.0001376406,0.002994393],"genre_scores_gemma":[0.9858892,0.001161802,0.004716876,0.00007743779,0.00002558576,0.00002825748,0.000734991,0.00007908102,0.007286707],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001347007,"threshold_uncertainty_score":0.004506171,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02247958299456598,"score_gpt":0.2397634969448545,"score_spread":0.2172839139502885,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}