{"id":"W2016127680","doi":"10.1016/j.nurt.2007.07.005","title":"Targeting MMPs in Acute and Chronic Neurological Conditions","year":2007,"lang":"en","type":"review","venue":"Neurotherapeutics","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":63,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of Calgary","funders":"","keywords":"Matrix metalloproteinase; Medicine; Downregulation and upregulation; Central nervous system; Multiple sclerosis; Neurology; Neuroscience; Neurosurgery; Bioinformatics; Immunology; Internal medicine; Biology; Surgery","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0001506219,0.0003269184,0.0005131026,0.00009977417,0.0000622462,0.00002694483,0.000189324,0.0005229836,0.00001987504],"category_scores_gemma":[0.00001814348,0.0002862881,0.0001552837,0.0001269017,0.00007802455,0.000002725478,0.00008942431,0.0004383252,0.00001284067],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001567643,"about_ca_system_score_gemma":0.0001257143,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":7.708256e-7,"about_ca_topic_score_gemma":0.000003063481,"domain_scores_codex":[0.9985102,0.0001540687,0.0003751793,0.0005091971,0.0001015728,0.0003498269],"domain_scores_gemma":[0.9994651,0.00002947122,0.0001301937,0.0002784299,0.00001964592,0.00007716229],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00004182391,0.0001910393,0.00002337685,0.002504654,0.0002652259,0.0002839272,0.00001521831,0.000004971698,0.05066602,0.0006271049,0.0007012888,0.9446753],"study_design_scores_gemma":[0.0002167136,0.0004788556,0.000001863957,0.0002635827,0.0001402667,0.0001088857,8.722802e-7,0.00002140227,0.001352646,0.00005635466,0.9970883,0.0002703124],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0004232038,0.9982509,0.0002041142,0.00002094855,0.0001992074,0.0006498576,0.00005591224,0.00001955183,0.0001763195],"genre_scores_gemma":[0.0002844554,0.9978883,0.0001192001,0.0008362284,0.0004141735,0.00007624571,0.0002029898,0.00006635683,0.0001120979],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.9963869,"threshold_uncertainty_score":0.9999589,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04209401027709576,"score_gpt":0.3458042616081801,"score_spread":0.3037102513310844,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}