{"id":"W2016158888","doi":"10.4161/cc.9.10.11752","title":"The Dbf4 motif C zinc finger promotes DNA replication and mediates resistance to genotoxic stress","year":2010,"lang":"en","type":"article","venue":"Cell Cycle","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Origin recognition complex; Pre-replication complex; DNA replication; Control of chromosome duplication; Minichromosome maintenance; DNA replication factor CDT1; G2-M DNA damage checkpoint; Origin of replication; Eukaryotic DNA replication; Replication factor C; Genetics; Licensing factor; Cell biology; Sequence motif; DNA repair; Helicase; Chromatin; DNA; Cell cycle; Cell cycle checkpoint; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001091974,0.0003542039,0.0002555982,0.0002282841,0.0001646308,0.0003147499,0.0002544221,0.0003071214,0.001093961],"category_scores_gemma":[0.0001181672,0.0001255931,0.0002625385,0.0001108776,0.0001554117,0.0001162449,0.0002831946,0.0002871299,0.0004042741],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004530412,"about_ca_system_score_gemma":0.0001767775,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009636616,"about_ca_topic_score_gemma":0.0007394499,"domain_scores_codex":[0.9998784,0.00001159677,0.000008705233,0.00002579617,0.00002689083,0.0000485689],"domain_scores_gemma":[0.9998791,0.000008918837,0.00003699136,0.00001607752,0.00001481128,0.00004413556],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00008655582,0.000009372656,0.0003717098,0.0000171396,0.00000407509,0.00003591581,0.000002927263,0.00003326278,0.9987268,0.00003844651,0.00002761118,0.0006461887],"study_design_scores_gemma":[0.00001513093,0.000129531,0.01564553,0.000004548113,0.00001034958,0.0003016535,0.00002145648,0.0007682419,0.9808251,0.00005754897,0.002213802,0.00000715048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9957678,0.001444611,0.001318473,0.00005955824,0.00001918952,0.00001519772,0.000199143,0.0001245592,0.001051365],"genre_scores_gemma":[0.9976315,0.0002356,0.0003202025,0.00001586009,0.0000038804,0.000008246832,0.000207143,0.000009443659,0.001568083],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001093961,"threshold_uncertainty_score":0.003659666,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004114669242465992,"score_gpt":0.2166647390214887,"score_spread":0.2125500697790227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}