{"id":"W2016158888","doi":"10.4161/cc.9.10.11752","title":"The Dbf4 motif C zinc finger promotes DNA replication and mediates resistance to genotoxic stress","year":2010,"lang":"en","type":"article","venue":"Cell Cycle","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":27,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Waterloo","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Biology; Origin recognition complex; Pre-replication complex; DNA replication; Control of chromosome duplication; Minichromosome maintenance; DNA replication factor CDT1; G2-M DNA damage checkpoint; Origin of replication; Eukaryotic DNA replication; Replication factor C; Genetics; Licensing factor; Cell biology; Sequence motif; DNA repair; Helicase; Chromatin; DNA; Cell cycle; Cell cycle checkpoint; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002203952,0.00009322722,0.00006106224,0.00001190806,0.0001431636,0.00004314334,0.0001982823,0.00009408899,0.000008761149],"category_scores_gemma":[0.000165367,0.00007347191,0.00002549321,0.00004408608,0.00005227575,0.000002867676,0.0001128827,0.00007572091,0.00001734449],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000004394896,"about_ca_system_score_gemma":0.00002025804,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000004896398,"about_ca_topic_score_gemma":0.0002394314,"domain_scores_codex":[0.999242,0.00002461567,0.0001124102,0.0003582415,0.00008542262,0.0001772925],"domain_scores_gemma":[0.9990816,0.00002266685,0.00005155426,0.0007144794,0.00004778275,0.00008190433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00001373196,0.00002020903,0.0002702287,0.00001167125,0.000004672031,5.401022e-7,0.00006273431,0.000001998854,0.9972346,0.0001003974,0.0006971321,0.001582094],"study_design_scores_gemma":[0.00009797381,0.00004642716,0.002436815,0.000004366552,0.00000520842,0.000001196858,0.00002721737,0.00003364215,0.974875,0.0005399428,0.02183505,0.00009720399],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9971195,0.0004199276,0.0001057819,0.0004624126,0.00013164,0.0002578889,0.00001137257,0.00002136582,0.001470047],"genre_scores_gemma":[0.9950657,0.00006287256,0.001555718,0.0001062769,0.0001410136,0.00005713978,0.00002370259,0.00001971774,0.002967804],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02235963,"threshold_uncertainty_score":0.2996098,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004114669242465992,"score_gpt":0.2166647390214887,"score_spread":0.2125500697790227,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}