{"id":"W2016159965","doi":"10.1016/j.healun.2010.08.001","title":"Endothelin-1 antagonism and nitric oxide augmentation prevents cyclosporine-induced vasomotor impairment","year":2010,"lang":"en","type":"article","venue":"The Journal of Heart and Lung Transplantation","topic":"Nitric Oxide and Endothelin Effects","field":"Medicine","cited_by":9,"is_retracted":false,"has_abstract":false,"ca_institutions":"Toronto General Hospital; University of Toronto; University Health Network","funders":"","keywords":"Bosentan; Medicine; Endothelial dysfunction; Enos; Endothelin receptor; Endothelin receptor antagonist; Nitric oxide; Vasoconstriction; Internal medicine; Vasospasm; Endothelin 1; Pharmacology; Endocrinology; Sodium nitroprusside; Endothelins; Nitric oxide synthase; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004291942,0.0007076912,0.00135291,0.0004397029,0.0006109792,0.0006993162,0.0008413422,0.0006273297,0.003568018],"category_scores_gemma":[0.0008621402,0.0002987823,0.0005158694,0.0002996718,0.001079024,0.000627476,0.0004399702,0.003073081,0.0004644027],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003322655,"about_ca_system_score_gemma":0.0009896302,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008445148,"about_ca_topic_score_gemma":0.00194993,"domain_scores_codex":[0.9996303,0.00007026103,0.0000314171,0.00003883218,0.0000717257,0.0001573316],"domain_scores_gemma":[0.9985368,0.0002483444,0.0002399059,0.000171326,0.00006211773,0.0007414598],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.04237858,0.005805576,0.001523587,0.000269626,0.0001345516,0.0008779792,0.0001424816,0.0006822245,0.9267178,0.0006913784,0.0005381699,0.02023797],"study_design_scores_gemma":[0.005407571,0.02775067,0.04432189,0.00005471047,0.0003377135,0.001360637,0.0002763728,0.004000797,0.9123463,0.0004626106,0.003618092,0.00006272867],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962968,0.0008656722,0.0005077908,0.000158683,0.0001838102,0.00005305217,0.0001208238,0.0001097267,0.001703634],"genre_scores_gemma":[0.9968153,0.000495031,0.0004623347,0.00008711233,0.000129847,0.00004398874,0.0002146705,0.00002626357,0.001725468],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.003568018,"threshold_uncertainty_score":0.01193625,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.008210074214851659,"score_gpt":0.2709030050223913,"score_spread":0.2626929308075397,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}