{"id":"W2016194054","doi":"10.1139/v02-094","title":"Structure-based rationalization of aldolase-catalyzed asymmetric synthesis","year":2002,"lang":"en","type":"article","venue":"Canadian Journal of Chemistry","topic":"Synthetic Organic Chemistry Methods","field":"Chemistry","cited_by":6,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"","keywords":"Aldolase A; Chemistry; Aldol reaction; Stereochemistry; Fructose-bisphosphate aldolase; Glyceraldehyde; Aldolase B; Catalysis; Enzyme; Organic chemistry","routes":{"ca_aff":false,"ca_fund":false,"ca_venue":true,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003380444,0.0005085354,0.0003084883,0.0002041755,0.0002397237,0.0005924045,0.0005688282,0.0003265167,0.0006663942],"category_scores_gemma":[0.0004363941,0.0002232002,0.0002837186,0.0001318892,0.000391834,0.000384877,0.0002194801,0.0009095983,0.0003148201],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009275114,"about_ca_system_score_gemma":0.0007622234,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008859665,"about_ca_topic_score_gemma":0.001268581,"domain_scores_codex":[0.9997948,0.00003815051,0.00001308582,0.00002682435,0.00009556807,0.00003162387],"domain_scores_gemma":[0.9999013,0.00002461587,0.0000196475,0.0000150281,0.00002619356,0.00001313192],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001741761,0.0001295106,0.000775277,0.0001925478,0.00003251186,0.000663775,0.00008345958,0.04044369,0.9151717,0.02636603,0.0002313211,0.01573584],"study_design_scores_gemma":[0.0000574765,0.0002130944,0.0002874678,0.00001234296,0.00002429061,0.0002742644,0.00004457989,0.04656303,0.9418001,0.002510268,0.008194354,0.00001875458],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8286394,0.003424168,0.1520051,0.0008920341,0.0002263097,0.0003369449,0.0003513493,0.0004731602,0.01365152],"genre_scores_gemma":[0.9328817,0.001987318,0.06287212,0.00007023972,0.00002252008,0.00006881222,0.000193014,0.00005171985,0.001852532],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009275114,"threshold_uncertainty_score":0.006729543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01642913258771856,"score_gpt":0.2171738575880945,"score_spread":0.2007447250003759,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}