{"id":"W2016240092","doi":"10.1038/ki.2012.223","title":"Overexpression of stanniocalcin-1 inhibits reactive oxygen species and renal ischemia/reperfusion injury in mice","year":2012,"lang":"en","type":"article","venue":"Kidney International","topic":"Physiological and biochemical adaptations","field":"Environmental Science","cited_by":80,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Institutes of Health","keywords":"Reactive oxygen species; Reperfusion injury; Ischemia; Superoxide; Kidney; Renal ischemia; Acute kidney injury; Genetically modified mouse; Mitochondrial permeability transition pore; Chemistry; Biology; Endocrinology; Medicine; Pharmacology; Internal medicine; Transgene; Cell biology; Biochemistry; Programmed cell death; Apoptosis","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.00008879787,0.00007526911,0.00008035891,0.00002487804,0.00002659751,0.000005468623,0.0001089705,0.00005572353,0.001282177],"category_scores_gemma":[0.000185375,0.0000560785,0.00002567119,0.00008156506,0.0001189275,0.0002441387,0.0002501064,0.0000983231,0.00002731499],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00007252108,"about_ca_system_score_gemma":0.000006674511,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00007014967,"about_ca_topic_score_gemma":0.000001434647,"domain_scores_codex":[0.9993231,0.00001946816,0.0001627796,0.0001483163,0.0002196188,0.0001267078],"domain_scores_gemma":[0.9997049,0.00003926216,0.00006915851,0.00005298574,0.00001139982,0.000122276],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005973635,0.0001415905,0.01533337,0.000002209998,0.000004117672,1.693349e-7,0.0001776071,0.000004199097,0.9779115,0.0002543057,0.00571106,0.0004001804],"study_design_scores_gemma":[0.0001755076,0.00002381635,0.09291393,0.00004796292,0.000002017505,0.000001369969,0.00004241301,0.0001090869,0.8986623,0.0007446006,0.007202183,0.0000747557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9817467,0.00001027058,0.0000262768,0.0006004629,0.00005622727,0.00005748433,0.00007465247,0.000007522685,0.01742036],"genre_scores_gemma":[0.998067,0.00001715167,0.000885061,0.0002860489,0.00006857829,0.000005761144,0.00005595488,0.000002994037,0.0006114967],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0792491,"threshold_uncertainty_score":0.9996308,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01320524052270325,"score_gpt":0.2426845808011308,"score_spread":0.2294793402784275,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}