{"id":"W2016248729","doi":"10.1172/jci30440","title":"Hypothalamic resistin induces hepatic insulin resistance","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Investigation","topic":"Adipokines, Inflammation, and Metabolic Diseases","field":"Medicine","cited_by":116,"is_retracted":false,"has_abstract":true,"ca_institutions":"University Health Network","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; National Cancer Institute; University of Toronto; National Institutes of Health; American Diabetes Association","keywords":"Resistin; Internal medicine; Endocrinology; Insulin resistance; Proinflammatory cytokine; Hypothalamus; Medicine; Insulin; Hormone; Inflammation; Adipokine","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":{"n_in":0,"stratum":"aff_core","weight":5595.2375,"opus":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"Physiology study of hypothalamic resistin and hepatic insulin resistance; the object is a metabolic mechanism."},"gpt":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"The study investigates hypothalamic resistin and insulin resistance, not research practice."},"grok":{"tier":"OUT","genre":"empirical","about_ca":false,"confidence":"high","reason":"Physiology study of hypothalamic resistin and insulin resistance; biomedical domain."}},"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00008500942,0.0003262448,0.0002392166,0.0001661741,0.00009418442,0.0002891234,0.00008433691,0.0001474593,0.001564022],"category_scores_gemma":[0.0001418477,0.0001327773,0.0001920419,0.0000785904,0.0003785897,0.0001419346,0.0002542146,0.0007200814,0.0002066635],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002497649,"about_ca_system_score_gemma":0.0001243594,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002096945,"about_ca_topic_score_gemma":0.0002593778,"domain_scores_codex":[0.9999201,0.00001584005,0.000005492248,0.00001745213,0.00001691278,0.00002420252],"domain_scores_gemma":[0.9999005,0.00001841949,0.00003093343,0.0000153476,0.000004207232,0.00003062341],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001161865,0.00004756416,0.0004347632,0.0000464092,0.00001449346,0.0004024883,0.00002458879,0.00007823293,0.9932331,0.0002547737,0.00008492923,0.00421677],"study_design_scores_gemma":[0.0003408823,0.002745129,0.02006009,0.00002392623,0.00005952828,0.002391604,0.000166941,0.001224339,0.9688454,0.0006028496,0.003522129,0.00001724496],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9954951,0.0009318939,0.001590648,0.0001720883,0.00006446083,0.00001209242,0.00007216855,0.00009920848,0.001562285],"genre_scores_gemma":[0.9976815,0.0005707887,0.0005967341,0.00007868485,0.00003752107,0.00001496274,0.00007321592,0.0000237324,0.000922865],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001564022,"threshold_uncertainty_score":0,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.07178106880786851,"score_gpt":0.3701004213354118,"score_spread":0.2983193525275433,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}