{"id":"W2016265973","doi":"10.1021/jm050280z","title":"Angiotensin II Pseudopeptides Containing 1,3,5-Trisubstituted Benzene Scaffolds with High AT<sub>2</sub>Receptor Affinity","year":2005,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Chemistry; Agonist; Receptor; Angiotensin II receptor type 1; Angiotensin II; Stereochemistry; Intrinsic activity; Benzene; Angiotensin receptor; Oligopeptide; Combinatorial chemistry; Peptide; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004233714,0.0002818276,0.0005098886,0.00004315061,0.000170467,0.00002133755,0.0002971379,0.0002561626,0.0001809993],"category_scores_gemma":[0.0002929232,0.0002118961,0.0002796013,0.0001641922,0.0001773326,0.00001375504,0.0001266506,0.0002296653,0.000006483254],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001209449,"about_ca_system_score_gemma":0.0001668377,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000007707164,"about_ca_topic_score_gemma":0.00001416328,"domain_scores_codex":[0.9982214,0.00003179867,0.0005847904,0.000303166,0.0005173014,0.000341538],"domain_scores_gemma":[0.9984159,0.00004829591,0.0005586668,0.0002736667,0.0003514967,0.0003519496],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007095125,0.0001531735,0.001426814,0.00002511382,0.000318676,0.00003818843,0.00002616794,0.000105037,0.9883178,0.000001146006,0.005428744,0.003449572],"study_design_scores_gemma":[0.001408128,0.0003505932,0.0006664905,0.0001928587,0.0002622624,0.000463314,0.00007075522,0.00001562412,0.984565,0.000004718617,0.01173642,0.0002639089],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968017,0.001510893,0.000142201,0.00117558,0.00005244955,0.00004212858,0.00001234833,0.00001001029,0.0002526451],"genre_scores_gemma":[0.9943691,0.000489166,0.002305719,0.0002908304,0.002271805,0.000002273005,0.00005225522,0.00002974153,0.0001891328],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.006307671,"threshold_uncertainty_score":0.8640873,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00543620084277405,"score_gpt":0.2056467757039257,"score_spread":0.2002105748611517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}