{"id":"W2016265973","doi":"10.1021/jm050280z","title":"Angiotensin II Pseudopeptides Containing 1,3,5-Trisubstituted Benzene Scaffolds with High AT<sub>2</sub>Receptor Affinity","year":2005,"lang":"en","type":"article","venue":"Journal of Medicinal Chemistry","topic":"Chemical Synthesis and Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":32,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Sherbrooke","funders":"","keywords":"Chemistry; Agonist; Receptor; Angiotensin II receptor type 1; Angiotensin II; Stereochemistry; Intrinsic activity; Benzene; Angiotensin receptor; Oligopeptide; Combinatorial chemistry; Peptide; Biochemistry; Organic chemistry","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001004967,0.0003769522,0.0002410121,0.0001010636,0.00007603227,0.0001909706,0.0001871607,0.0001694077,0.0009512718],"category_scores_gemma":[0.0001228797,0.000110035,0.0001464151,0.0001659236,0.0001092843,0.0001896008,0.0001179635,0.0002944531,0.0004608158],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002180732,"about_ca_system_score_gemma":0.000134563,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003005138,"about_ca_topic_score_gemma":0.0007419045,"domain_scores_codex":[0.9999306,0.00001768048,0.000004537143,0.00001067437,0.00001515115,0.00002137152],"domain_scores_gemma":[0.9999033,0.00001484761,0.00003580236,0.000005507923,0.00001284619,0.00002765479],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001569804,0.00001978529,0.0001146308,0.00004987883,0.000006571556,0.00005396022,0.00001392349,0.0003682349,0.996403,0.0001363039,0.00003543512,0.002641225],"study_design_scores_gemma":[0.00004097689,0.001509366,0.002001323,0.000005829711,0.00003488895,0.0002719204,0.00001787591,0.0008129659,0.9916775,0.00003756015,0.003579291,0.00001041262],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.990181,0.002325555,0.00538343,0.00004597607,0.00003422437,0.00004965598,0.0002898216,0.0000767559,0.001613599],"genre_scores_gemma":[0.9894567,0.001532087,0.00709124,0.00006009742,0.00001502106,0.00003630577,0.0004064679,0.00001507161,0.00138697],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009512718,"threshold_uncertainty_score":0.003182292,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.00543620084277405,"score_gpt":0.2056467757039257,"score_spread":0.2002105748611517,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}