{"id":"W2016290546","doi":"10.1111/j.1365-2710.2007.00870.x","title":"Pharmacogenetics of acenocoumarol: CYP2C9, CYP2C19, CYP1A2, CYP3A4, CYP3A5 and ABCB1 gene polymorphisms and dose requirements","year":2007,"lang":"en","type":"article","venue":"Journal of Clinical Pharmacy and Therapeutics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Agence Universitaire de la Francophonie","keywords":"CYP2C9; CYP2C19; Acenocoumarol; Pharmacogenetics; CYP3A5; CYP1A2; CYP3A4; Pharmacology; VKORC1; Genetics; Medicine; Gene; Biology; Cytochrome P450; Warfarin; Genotype; Biochemistry; Internal medicine; Microsome; Enzyme; In vitro","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.007597956,0.0005677245,0.00133094,0.0003477533,0.0002879053,0.0000519153,0.0004896579,0.0004322643,0.000218767],"category_scores_gemma":[0.0001574317,0.0004864388,0.0003424272,0.0003062059,0.001189202,0.000295997,0.0003103507,0.001805581,0.000005468718],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002533603,"about_ca_system_score_gemma":0.0002218132,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00001074419,"about_ca_topic_score_gemma":0.00000298604,"domain_scores_codex":[0.9941043,0.0008244549,0.003154832,0.0005091545,0.000612872,0.0007944001],"domain_scores_gemma":[0.9943749,0.001762109,0.001886888,0.0002646431,0.0005262262,0.001185227],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.005945635,0.0013652,0.1904874,0.0001252004,0.002207574,0.0002351481,0.0009016097,0.00004589622,0.2974046,0.0003360806,0.0003267709,0.5006189],"study_design_scores_gemma":[0.03052024,0.001144973,0.08632989,0.00008747919,0.004044688,0.0008856942,0.0001728379,0.002820202,0.2641066,0.003252538,0.605677,0.000957855],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9487864,0.04550578,0.0005304388,0.0011406,0.002749278,0.0004432558,0.00008538077,0.00002428982,0.0007346132],"genre_scores_gemma":[0.8717656,0.1190543,0.00183853,0.005807627,0.001333035,0.000003220529,0.000004698158,0.00006399508,0.0001289867],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.6053503,"threshold_uncertainty_score":0.9997587,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.3170457196764959,"score_gpt":0.5557127096929809,"score_spread":0.2386669900164851,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}