{"id":"W2016313081","doi":"10.1016/j.ymgme.2007.02.001","title":"Metabolic derangement of methionine and folate metabolism in mice deficient in methionine synthase reductase","year":2007,"lang":"en","type":"article","venue":"Molecular Genetics and Metabolism","topic":"Folate and B Vitamins Research","field":"Medicine","cited_by":114,"is_retracted":false,"has_abstract":false,"ca_institutions":"Montreal Children's Hospital; McGill University; University of Calgary","funders":"National Institute of General Medical Sciences; National Institute of Diabetes and Digestive and Kidney Diseases; National Heart, Lung, and Blood Institute","keywords":"MTRR; Methionine synthase; Methionine; Homocystinuria; Thymidylate synthase; Cystathionine beta synthase; Homocysteine; Biochemistry; Reductase; Chemistry; Methylenetetrahydrofolate reductase; Biosynthesis; Enzyme; Biology; Internal medicine; Gene; Amino acid; Medicine; Allele","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007061014,0.002349149,0.001369351,0.003369038,0.0008619842,0.001202689,0.001219077,0.002346395,0.005059324],"category_scores_gemma":[0.0006496601,0.001460261,0.00120745,0.0009728219,0.002603594,0.0009745813,0.0007549613,0.003023777,0.001059706],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.001077718,"about_ca_system_score_gemma":0.000917479,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002620745,"about_ca_topic_score_gemma":0.002433408,"domain_scores_codex":[0.9989066,0.0001768925,0.0001470549,0.0003016879,0.0002203112,0.0002474188],"domain_scores_gemma":[0.998078,0.0002881371,0.0008278093,0.0001633678,0.00008178331,0.0005608959],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002497884,0.0002105017,0.0004985416,0.00006199945,0.00005465743,0.0005904984,0.00007881546,0.0002365816,0.993809,0.0007434697,0.0001443971,0.001073657],"study_design_scores_gemma":[0.0006957409,0.001476237,0.007305073,0.00005137889,0.0003371829,0.003428897,0.0003396227,0.002086776,0.9804885,0.001111852,0.002596332,0.00008235849],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9892406,0.00178775,0.004094561,0.0008629469,0.0001663299,0.00008205848,0.001825775,0.0006138278,0.001326055],"genre_scores_gemma":[0.9855859,0.001517783,0.003522087,0.0002830373,0.00008291774,0.0001588662,0.001068198,0.0003711707,0.007409987],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005059324,"threshold_uncertainty_score":0.01692516,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01502076680336978,"score_gpt":0.3032855003473253,"score_spread":0.2882647335439555,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}