{"id":"W2016320036","doi":"10.1158/0008-5472.can-06-1042","title":"Association with HSP90 Inhibits Cbl-Mediated Down-regulation of Mutant Epidermal Growth Factor Receptors","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; Vanderbilt University","keywords":"Epidermal growth factor receptor; Geldanamycin; Hsp90; Mutant; Ubiquitin ligase; Cell biology; Tyrosine kinase; GRB2; Receptor; Signal transducing adaptor protein; Receptor tyrosine kinase; Biology; Epidermal growth factor; Cancer research; Growth factor receptor; Phosphorylation; Chemistry; Molecular biology; Signal transduction; Ubiquitin; Biochemistry; Heat shock protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001824546,0.0003842714,0.0003992934,0.0001770366,0.0001629252,0.0003742586,0.0003180347,0.0001700178,0.001192823],"category_scores_gemma":[0.0001892637,0.0001532084,0.0002817658,0.0001634903,0.0002322247,0.0001252995,0.0003166011,0.0006839285,0.0008054536],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000401249,"about_ca_system_score_gemma":0.0002523036,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0009115874,"about_ca_topic_score_gemma":0.001566785,"domain_scores_codex":[0.9997832,0.00005039071,0.00001572712,0.00001998809,0.00005265437,0.00007803684],"domain_scores_gemma":[0.9998789,0.00001839254,0.00002655552,0.00002886574,0.000009847746,0.00003738056],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000230542,0.0001442064,0.0001686611,0.0000457835,0.00001677802,0.00005051409,0.00001406755,0.0001299757,0.9971915,0.00007647794,0.0001536522,0.001777871],"study_design_scores_gemma":[0.00005979952,0.0004840723,0.004025697,0.000007107782,0.00001565965,0.0002384049,0.0000184515,0.001273708,0.9922665,0.00002353582,0.00158238,0.000004667113],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9965978,0.001232856,0.0007208824,0.00009925229,0.00002786278,0.00001534481,0.0001733351,0.0001509323,0.0009816256],"genre_scores_gemma":[0.9966154,0.0005340709,0.000410274,0.00004254581,0.00000824829,0.00002065161,0.00051087,0.00002743765,0.001830624],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001192823,"threshold_uncertainty_score":0.003990412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02513040464905288,"score_gpt":0.3290442043960595,"score_spread":0.3039137997470067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}