{"id":"W2016320036","doi":"10.1158/0008-5472.can-06-1042","title":"Association with HSP90 Inhibits Cbl-Mediated Down-regulation of Mutant Epidermal Growth Factor Receptors","year":2006,"lang":"en","type":"article","venue":"Cancer Research","topic":"Heat shock proteins research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":79,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Cancer Institute; Vanderbilt University","keywords":"Epidermal growth factor receptor; Geldanamycin; Hsp90; Mutant; Ubiquitin ligase; Cell biology; Tyrosine kinase; GRB2; Receptor; Signal transducing adaptor protein; Receptor tyrosine kinase; Biology; Epidermal growth factor; Cancer research; Growth factor receptor; Phosphorylation; Chemistry; Molecular biology; Signal transduction; Ubiquitin; Biochemistry; Heat shock protein","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00096947,0.0001392697,0.0001857341,0.000200138,0.0001360901,0.00003327779,0.0002206309,0.0002636944,0.0002978982],"category_scores_gemma":[0.0006429211,0.0001188353,0.00005263095,0.0006121563,0.0001579382,0.00001333501,0.0001295027,0.0003367191,0.00002892102],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003493951,"about_ca_system_score_gemma":0.0005917884,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001975625,"about_ca_topic_score_gemma":0.0007074022,"domain_scores_codex":[0.9971614,0.0004092379,0.0002914498,0.000409017,0.001098512,0.0006303494],"domain_scores_gemma":[0.9981516,0.00009892052,0.0001004047,0.0002922929,0.001233343,0.000123431],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0002291041,0.00006117719,0.04752919,0.00005770465,0.00004931365,0.000001785105,0.00003440276,0.00006296525,0.9472623,0.00003572318,0.004058309,0.0006180329],"study_design_scores_gemma":[0.0006881684,0.0003112703,0.03515517,0.00004239542,0.000004134657,0.000001374827,0.00002438825,0.00002748827,0.9570096,0.00005173568,0.006550499,0.0001337828],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9968645,0.0003388673,0.0001864958,0.0008871835,0.00005375167,0.0006115696,0.00009893404,0.00001252984,0.0009461603],"genre_scores_gemma":[0.9963568,0.0001782926,0.00009957841,0.00001762995,0.0003482475,0.0001723568,0.0002431656,0.00003626872,0.002547685],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01237403,"threshold_uncertainty_score":0.4845964,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02513040464905288,"score_gpt":0.3290442043960595,"score_spread":0.3039137997470067,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}