{"id":"W2016329603","doi":"10.1371/journal.pone.0000510","title":"Molecular Dynamics of Retinoic Acid-Induced Craniofacial Malformations: Implications for the Origin of Gnathostome Jaws","year":2007,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Developmental Biology and Gene Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":51,"is_retracted":false,"has_abstract":true,"ca_institutions":"Ontario Genomics; University of Ottawa","funders":"","keywords":"Craniofacial; Retinoic acid; Biology; Neural crest; FGF8; Endoderm; Anatomy; Morphogenesis; Cell biology; Internal medicine; Endocrinology; Genetics; Receptor; Cellular differentiation; Embryo; Medicine; Gene; Fibroblast growth factor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000116334,0.0001833358,0.0001699238,0.0003179765,0.0001456681,0.0002768773,0.0001886468,0.0003259149,0.00171804],"category_scores_gemma":[0.0001598651,0.0001076097,0.0001562278,0.0001496108,0.0003026247,0.000282881,0.0001865261,0.0002395891,0.0003132725],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003491174,"about_ca_system_score_gemma":0.0001404077,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003490236,"about_ca_topic_score_gemma":0.0003676632,"domain_scores_codex":[0.9999332,0.00001041111,0.00000512341,0.00002475218,0.00001407659,0.00001241385],"domain_scores_gemma":[0.9999042,0.00001753878,0.00004155015,0.00001044934,0.000009697101,0.00001654263],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00009093927,0.000006190691,0.0009791029,0.00003825571,0.000002693329,0.00009561625,0.00001991925,0.0001646137,0.996305,0.0007092233,0.00002431127,0.001564139],"study_design_scores_gemma":[0.00003048528,0.0003984804,0.1534827,0.00003078253,0.00004501189,0.001810768,0.0002636199,0.004739515,0.8310105,0.001644844,0.006512416,0.00003095097],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9796056,0.006162958,0.008684346,0.0002169895,0.00003026537,0.00002910278,0.0007081936,0.0001826796,0.004379905],"genre_scores_gemma":[0.9935417,0.001660209,0.002580027,0.00002614508,0.000008926792,0.00002745034,0.0002023522,0.00001394168,0.001939252],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00171804,"threshold_uncertainty_score":0.005747437,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02767170003749407,"score_gpt":0.2705251186189069,"score_spread":0.2428534185814128,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}