{"id":"W2016332494","doi":"10.1159/000177938","title":"Is There a Difference between Levodopa/ Dopa-Decarboxylase Inhibitor and Entacapone and Levodopa/Dopa-Decarboxylase Inhibitor Dose Fractionation Strategies in Parkinson’s Disease Patients Experiencing Symptom Re-Emergence due to Wearing-Off?","year":2008,"lang":"en","type":"article","venue":"European Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders","funders":"Novartis Pharma; Novartis","keywords":"Entacapone; Levodopa; Decarboxylase inhibitor; Medicine; Benserazide; Aromatic L-amino acid decarboxylase; Parkinson's disease; Selegiline; Internal medicine; Gastroenterology; Disease; Dopamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0002003144,0.0005600876,0.0006147263,0.0004326046,0.0003080579,0.00007004348,0.0001796097,0.00008841429,0.0001051709],"category_scores_gemma":[0.0002069884,0.0005327675,0.00009864427,0.0003555705,0.0001952211,0.0003656361,0.0003213885,0.0004443162,0.00006196969],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0000833355,"about_ca_system_score_gemma":0.0001464562,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001696287,"about_ca_topic_score_gemma":0.00005055619,"domain_scores_codex":[0.996379,0.000523738,0.0006444298,0.001295725,0.0005218189,0.0006353442],"domain_scores_gemma":[0.9980592,0.0001652201,0.0002359722,0.0005211966,0.0001206638,0.0008977957],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.001853173,0.0008713701,0.9767539,0.00009626171,0.00007912087,0.006401119,0.003253754,0.00001378148,0.002809739,0.00004232329,0.0002981088,0.007527382],"study_design_scores_gemma":[0.004179726,0.001264878,0.9890782,0.000125575,0.0001124887,0.00009564033,0.0002824437,0.0002371476,0.0008026868,0.00008448624,0.003320191,0.0004165146],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9960634,0.001095405,0.00005622654,0.0007289528,0.0003733232,0.0009063126,0.0001036789,0.000131211,0.0005415534],"genre_scores_gemma":[0.9973531,0.0007297257,0.0001305434,0.001044006,0.0003499059,0.00008531018,0.00007255403,0.000102067,0.0001328403],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.01232436,"threshold_uncertainty_score":0.9997124,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02514954739966206,"score_gpt":0.2597854517000949,"score_spread":0.2346359043004329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}