{"id":"W2016332494","doi":"10.1159/000177938","title":"Is There a Difference between Levodopa/ Dopa-Decarboxylase Inhibitor and Entacapone and Levodopa/Dopa-Decarboxylase Inhibitor Dose Fractionation Strategies in Parkinson’s Disease Patients Experiencing Symptom Re-Emergence due to Wearing-Off?","year":2008,"lang":"en","type":"article","venue":"European Neurology","topic":"Parkinson's Disease Mechanisms and Treatments","field":"Medicine","cited_by":11,"is_retracted":false,"has_abstract":true,"ca_institutions":"Centre for Movement Disorders","funders":"Novartis Pharma; Novartis","keywords":"Entacapone; Levodopa; Decarboxylase inhibitor; Medicine; Benserazide; Aromatic L-amino acid decarboxylase; Parkinson's disease; Selegiline; Internal medicine; Gastroenterology; Disease; Dopamine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001421854,0.0005162925,0.001997593,0.0003077037,0.0002141775,0.0006343083,0.0005568747,0.001683151,0.00161031],"category_scores_gemma":[0.001901265,0.0003939271,0.001387677,0.000285769,0.0005637226,0.0008068829,0.0001984393,0.001494958,0.0002166833],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003749951,"about_ca_system_score_gemma":0.0003999824,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005655648,"about_ca_topic_score_gemma":0.001924925,"domain_scores_codex":[0.9993024,0.0004017674,0.00007729642,0.00007957913,0.00005184717,0.00008717474],"domain_scores_gemma":[0.9986083,0.0006134714,0.0002828271,0.00007533563,0.00005863587,0.0003613407],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"randomized_trial","study_design_gemma":"nonrandomized_trial","study_design_scores_codex":[0.8977281,0.01041913,0.003003712,0.000639844,0.00161405,0.00006603271,0.0001308735,0.0003815535,0.00534585,0.0001543357,0.0002275289,0.08028898],"study_design_scores_gemma":[0.6026431,0.3769506,0.01612279,0.0001063129,0.001335819,0.0001094816,0.00009269163,0.000642013,0.0009810454,0.000253336,0.0007306829,0.00003215206],"study_design_candidate":"nonrandomized_trial","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.993531,0.00504848,0.0001444902,0.0002894823,0.0001275286,0.0002271286,0.00005550131,0.00001278722,0.0005635277],"genre_scores_gemma":[0.9966341,0.001878143,0.0003967036,0.0004437862,0.0001462232,0.0001686787,0.00007732048,0.000002893092,0.0002520944],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001997593,"threshold_uncertainty_score":0.007519543,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02514954739966206,"score_gpt":0.2597854517000949,"score_spread":0.2346359043004329,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}