{"id":"W2016340867","doi":"10.1152/ajpcell.00310.2013","title":"Degradation mechanism of a Golgi-retained distal renal tubular acidosis mutant of the kidney anion exchanger 1 in renal cells","year":2014,"lang":"en","type":"article","venue":"American Journal of Physiology-Cell Physiology","topic":"Ion Transport and Channel Regulation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":13,"is_retracted":false,"has_abstract":true,"ca_institutions":"McGill University; University of Alberta","funders":"Canadian Institutes of Health Research","keywords":"Golgi apparatus; Mutant; Lysosome; Distal renal tubular acidosis; Cell biology; Kidney; Biology; Chemistry; Biochemistry; Endocrinology; Enzyme; Acidosis; Endoplasmic reticulum; Gene","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003189477,0.0002136904,0.0005871238,0.000119724,0.0000430012,0.000002351719,0.0003591517,0.0001483462,0.00003432183],"category_scores_gemma":[0.00004491259,0.0001541789,0.0003074245,0.000251068,0.0004724616,0.00001187091,0.00006848959,0.0001964661,0.000001238862],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00002029624,"about_ca_system_score_gemma":0.0001145681,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000395009,"about_ca_topic_score_gemma":0.000008460896,"domain_scores_codex":[0.9982034,0.0004034435,0.0006768077,0.0002757175,0.0001744627,0.0002661468],"domain_scores_gemma":[0.9981219,0.00003553442,0.001205121,0.0003351229,0.0002167639,0.00008554909],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007450801,0.0002109571,0.00006245521,0.00003915616,0.00006670356,5.027474e-7,0.0001473199,0.0007386135,0.9972074,0.0001557868,0.0001084906,0.0005175317],"study_design_scores_gemma":[0.001193064,0.001898464,0.007759941,0.00005344247,0.00005941741,0.000008967902,0.0001671519,0.0004010313,0.9866431,0.001283028,0.000380326,0.0001520659],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9977145,0.00005843977,0.001675307,0.0001363092,0.0002240334,0.0001279917,0.00002619118,0.000002683833,0.000034506],"genre_scores_gemma":[0.9989551,0.0001046311,0.0003808629,0.0001642561,0.0002469357,0.000004598796,0.00008574153,0.00002102395,0.00003682546],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0105643,"threshold_uncertainty_score":0.6287235,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003769412921782561,"score_gpt":0.1918140513731566,"score_spread":0.188044638451374,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}