{"id":"W2016345267","doi":"10.1038/sj.bjc.6603863","title":"MT1-MMP is the critical determinant of matrix degradation and invasion by ovarian cancer cells","year":2007,"lang":"en","type":"article","venue":"British Journal of Cancer","topic":"Protease and Inhibitor Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":66,"is_retracted":false,"has_abstract":true,"ca_institutions":"Lunenfeld-Tanenbaum Research Institute; University of Toronto","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Matrix metalloproteinase; Gelatinase; Motility; Ovarian cancer; Biology; Cancer research; Ectopic expression; Metastasis; Cell culture; Matrix metalloproteinase inhibitor; Cell; Cancer cell; Cell biology; Gelatinase A; Cancer; Biochemistry; Genetics","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003481203,0.0000684246,0.0001176516,0.00001941588,0.00006508386,0.00002690284,0.0001003525,0.00008949699,0.00005580744],"category_scores_gemma":[0.00004785241,0.00005804983,0.00006304217,0.00004160488,0.00006734743,0.00001101968,0.00003328051,0.0001075503,2.399059e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001644618,"about_ca_system_score_gemma":0.00009300993,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004528575,"about_ca_topic_score_gemma":0.000310076,"domain_scores_codex":[0.9992819,0.00003330404,0.0002735716,0.0001064487,0.0001628234,0.0001419365],"domain_scores_gemma":[0.9995035,0.00001703107,0.0001603316,0.00007336577,0.0001731929,0.00007258583],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000765025,0.00002310421,0.0002024301,0.00002115095,0.00002197783,0.00001862502,0.00002118051,9.047776e-7,0.9394329,0.00001311749,0.007594164,0.05257393],"study_design_scores_gemma":[0.0003873211,0.0001581672,0.0007043352,0.0001841456,0.00003978292,0.0002351078,0.00003564016,0.000009045766,0.9803878,0.0001160785,0.01766764,0.00007491658],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9576829,0.0382278,0.003135435,0.0004168605,0.0003263927,0.00009015519,0.00006883623,0.00000117225,0.0000504569],"genre_scores_gemma":[0.989557,0.009054349,0.0004341324,0.0004342368,0.0003532237,0.000003883226,0.000002462957,0.00001064834,0.0001500982],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.05249902,"threshold_uncertainty_score":0.2367203,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0077445142826772,"score_gpt":0.2841690381583435,"score_spread":0.2764245238756664,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}