{"id":"W2016375830","doi":"10.1038/ki.2008.621","title":"TTP/HUS: observational studies generate hypotheses that lead to randomized controlled trials","year":2009,"lang":"en","type":"review","venue":"Kidney International","topic":"Complement system in diseases","field":"Immunology and Microbiology","cited_by":15,"is_retracted":false,"has_abstract":false,"ca_institutions":"Western University","funders":"","keywords":"Observational study; Randomized controlled trial; Medicine; Lead (geology); Intensive care medicine; Internal medicine; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.05913062,0.001920739,0.01379313,0.002595118,0.0004397249,0.003227621,0.005331227,0.006439197,0.00754196],"category_scores_gemma":[0.1353292,0.0007904107,0.004417569,0.002694837,0.002887901,0.003255352,0.0013505,0.005511495,0.001321749],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.002334728,"about_ca_system_score_gemma":0.004342108,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0008371953,"about_ca_topic_score_gemma":0.0009871742,"domain_scores_codex":[0.9769351,0.01350465,0.004307458,0.002553382,0.00235226,0.000347083],"domain_scores_gemma":[0.6754246,0.3072207,0.008966662,0.003593281,0.003817863,0.0009768873],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.01066728,0.0003490368,0.001390912,0.1733798,0.02031163,0.0003057749,0.00006874587,0.001141834,0.0005569932,0.01537232,0.03809099,0.7383647],"study_design_scores_gemma":[0.04931508,0.00521442,0.008576597,0.3408341,0.1025792,0.001499136,0.0003841217,0.00274942,0.001979469,0.1850627,0.3014279,0.0003778394],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0002988929,0.991429,0.001324462,0.004012527,0.002251937,0.0001246028,0.0001544305,0.00001633791,0.0003877779],"genre_scores_gemma":[0.01302873,0.9563887,0.006834078,0.0155564,0.006659536,0.0007690358,0.0003085429,0.00002182228,0.0004332044],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.05913062,"threshold_uncertainty_score":0.3127164,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.4100571584640607,"score_gpt":0.4614436651084086,"score_spread":0.05138650664434796,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}