{"id":"W2016439178","doi":"10.1042/bj20140126","title":"The cardiac ryanodine receptor luminal Ca2+ sensor governs Ca2+ waves, ventricular tachyarrhythmias and cardiac hypertrophy in calsequestrin-null mice","year":2014,"lang":"en","type":"article","venue":"Biochemical Journal","topic":"Cardiac electrophysiology and arrhythmias","field":"Medicine","cited_by":18,"is_retracted":false,"has_abstract":true,"ca_institutions":"Libin Cardiovascular Institute of Alberta; University of Calgary","funders":"National Heart, Lung, and Blood Institute","keywords":"Calsequestrin; Catecholaminergic polymorphic ventricular tachycardia; Ryanodine receptor; Ryanodine receptor 2; Internal medicine; Endocrinology; Biology; Cardiology; Receptor; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002873158,0.0008992896,0.0004836762,0.001051503,0.0003680701,0.0004780065,0.000425661,0.0009317456,0.002299079],"category_scores_gemma":[0.0002706179,0.0005112292,0.0005589219,0.0002705847,0.0008606981,0.0005629288,0.0006318144,0.001119154,0.0005659676],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002571989,"about_ca_system_score_gemma":0.0002284348,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004956701,"about_ca_topic_score_gemma":0.001236391,"domain_scores_codex":[0.9995652,0.00004225302,0.00008131692,0.0001560923,0.00009148866,0.00006373211],"domain_scores_gemma":[0.9993728,0.00006666443,0.0002701553,0.00004282128,0.00002703209,0.0002204991],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001762434,0.00003429738,0.0004828155,0.0000195309,0.000007124698,0.0002282278,0.00003152706,0.00004385824,0.9983019,0.0001106061,0.00003068165,0.0005331569],"study_design_scores_gemma":[0.0002828045,0.001038112,0.05611275,0.00005852616,0.0001336771,0.006601625,0.0002833941,0.003351544,0.9277505,0.0005911557,0.003739014,0.00005681048],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.991805,0.0004893235,0.005487957,0.0001525628,0.00003339314,0.0000559424,0.0009953125,0.0001486974,0.0008318776],"genre_scores_gemma":[0.9866102,0.0008035033,0.005498137,0.000146632,0.0000408732,0.0001899569,0.001152503,0.0002203673,0.00533779],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002299079,"threshold_uncertainty_score":0.007691145,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.005823517138499687,"score_gpt":0.2236338552646699,"score_spread":0.2178103381261702,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}