{"id":"W2016472471","doi":"10.1038/jcbfm.2008.110","title":"Evaluation of the Novel 5-HT <sub>4</sub> Receptor PET Ligand [ <sup>11</sup> C]SB207145 in the Göttingen Minipig","year":2008,"lang":"en","type":"article","venue":"Journal of Cerebral Blood Flow & Metabolism","topic":"Receptor Mechanisms and Signaling","field":"Biochemistry, Genetics and Molecular Biology","cited_by":56,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Division of Electrical, Communications and Cyber Systems; McGill University","keywords":"Radioligand; Binding potential; Receptor; Striatum; In vivo; Ligand (biochemistry); Radioligand Assay; 5-HT receptor; Positron emission tomography; Human brain; Chemistry; Binding site; Biophysics; Biology; Serotonin; Endocrinology; Neuroscience; Biochemistry","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005270023,0.001097646,0.0006070056,0.0002205504,0.0001968688,0.0005995044,0.0006839741,0.0008965344,0.001379543],"category_scores_gemma":[0.0004059346,0.0003354139,0.0003316999,0.0001506024,0.0005121212,0.0005563205,0.0002024137,0.0004827497,0.0004679124],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0005734471,"about_ca_system_score_gemma":0.0003568939,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.002006625,"about_ca_topic_score_gemma":0.002550123,"domain_scores_codex":[0.9997013,0.0001221957,0.00001003576,0.00006850549,0.00005302485,0.00004490537],"domain_scores_gemma":[0.999818,0.00003633755,0.00004793968,0.00002450453,0.00002834249,0.00004489253],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.003960536,0.0004177917,0.0009959883,0.0003304909,0.00009057772,0.0009802366,0.0001668175,0.001864004,0.9713876,0.0002748913,0.0002781486,0.01925293],"study_design_scores_gemma":[0.0003314541,0.0667773,0.01466277,0.00007316613,0.0005884373,0.002765371,0.000373225,0.004577207,0.8948011,0.0001760967,0.01479699,0.0000768533],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9877664,0.00205021,0.007472363,0.0001416963,0.00003739361,0.0004198615,0.0004992023,0.0001245236,0.001488217],"genre_scores_gemma":[0.9820856,0.003854483,0.007717771,0.000207395,0.00001936434,0.0005471816,0.001160941,0.0000616547,0.004345718],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002006625,"threshold_uncertainty_score":0.004615068,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01893027346853453,"score_gpt":0.2350478980005718,"score_spread":0.2161176245320373,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}