{"id":"W2016490545","doi":"10.1371/journal.pone.0074158","title":"Mitochondrial Haplotypes Associated with Biomarkers for Alzheimer’s Disease","year":2013,"lang":"en","type":"article","venue":"PLoS ONE","topic":"Alzheimer's disease research and treatments","field":"Medicine","cited_by":29,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Canadian Institutes of Health Research; National Institute of Biomedical Imaging and Bioengineering; U.S. Public Health Service; National Institutes of Health; Eisai; University of California, San Diego; BioClinica; Bayer HealthCare; Alzheimer's Disease Neuroimaging Initiative; Northern California Institute for Research and Education; University of California, Los Angeles; Brigham Young University; Biogen; Bristol-Myers Squibb; Eli Lilly and Company; AstraZeneca; Amorfix Life Sciences; National Institute on Aging; Alzheimer's Association; Foundation for the National Institutes of Health","keywords":"Endophenotype; Haplotype; Neuroimaging; Alzheimer's disease; Disease; Mitochondrial DNA; Biology; Dementia; Brain size; Neuroscience; Genetics; Medicine; Cognition; Pathology; Allele; Gene; Magnetic resonance imaging","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0008914277,0.0002027297,0.0002946991,0.0009079774,0.0003329999,0.0003384187,0.000166407,0.0002527139,0.001382612],"category_scores_gemma":[0.002649937,0.0001224397,0.0002333533,0.0006726771,0.0002310035,0.0003227007,0.0003608854,0.0003013191,0.0001095389],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001288301,"about_ca_system_score_gemma":0.0001498168,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001062144,"about_ca_topic_score_gemma":0.001757822,"domain_scores_codex":[0.9995741,0.0001584976,0.00005204722,0.00009855477,0.00005275629,0.00006400031],"domain_scores_gemma":[0.9977221,0.0006083889,0.00109148,0.0001706472,0.0001831598,0.0002241982],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"observational","study_design_gemma":"observational","study_design_scores_codex":[0.0003398887,0.00002984827,0.9896894,0.00001034003,0.0001308422,0.0001317381,0.0001879293,0.0001640885,0.00500709,0.00009177759,0.00006189467,0.004155104],"study_design_scores_gemma":[0.000008546747,0.0001091155,0.9982956,0.00000494913,0.00004388047,0.0003496834,0.0000747887,0.0002690777,0.0004481371,0.0002445732,0.0001462141,0.000005460968],"study_design_candidate":"observational","study_design_consensus":"observational","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9992039,0.0001934852,0.0002884489,0.00002392024,0.000002665374,0.000002970319,0.0001229223,0.000002622073,0.000159195],"genre_scores_gemma":[0.9994622,0.00003881369,0.0003308727,0.000007003779,0.000003542248,0.000002396124,0.0001068881,0.000001587155,0.00004672516],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001382612,"threshold_uncertainty_score":0.004714429,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06850623787951866,"score_gpt":0.2845314901468968,"score_spread":0.2160252522673781,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}