{"id":"W2016493248","doi":"10.1158/1078-0432.ccr-06-0547","title":"DNA Repair Pathway Profiling and Microsatellite Instability in Colorectal Cancer","year":2006,"lang":"en","type":"article","venue":"Clinical Cancer Research","topic":"Epigenetics and DNA Methylation","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"Immunovaccine (Canada)","funders":"National Institute of General Medical Sciences; National Cancer Institute; National Institutes of Health; Alvin J. Siteman Cancer Center","keywords":"DNA repair; Biology; MSH2; Microsatellite instability; XRCC1; DNA mismatch repair; MLH1; Cancer research; Gene; Colorectal cancer; Gene expression profiling; Genome instability; DNA damage; Gene expression; Molecular biology; DNA; Cancer; Genetics; Microsatellite","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003025531,0.0002031994,0.0002147026,0.0009995983,0.0001527174,0.0002850142,0.000117294,0.0002311747,0.0006711751],"category_scores_gemma":[0.0007657033,0.0001147342,0.000109773,0.0005380854,0.0001552061,0.0001409297,0.000203951,0.0001938585,0.0001329434],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002550606,"about_ca_system_score_gemma":0.0001301665,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005511895,"about_ca_topic_score_gemma":0.001043185,"domain_scores_codex":[0.9997938,0.00004346695,0.00001945552,0.00006709698,0.00005111952,0.000025066],"domain_scores_gemma":[0.9995112,0.00009447832,0.0002512167,0.00001589045,0.00007263052,0.00005448123],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.00185372,0.00005886722,0.4455847,0.0004307736,0.0001628954,0.0002927624,0.0001370697,0.0005102123,0.525909,0.00006127086,0.0001973822,0.02480146],"study_design_scores_gemma":[0.00001905425,0.0005553704,0.9321301,0.00001985191,0.0001173401,0.002209201,0.00009442191,0.001138902,0.0627076,0.0001375412,0.000859141,0.00001136185],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9958293,0.00305841,0.0006103446,0.00003386432,0.000003409815,0.000009573073,0.0002271778,0.0000326191,0.0001952224],"genre_scores_gemma":[0.9981644,0.0004167365,0.0008990355,0.00002189445,0.000005064838,0.00001148216,0.0002940572,0.000004318474,0.0001830068],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0009995983,"threshold_uncertainty_score":0.002245307,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.08811990991537905,"score_gpt":0.4505144735389585,"score_spread":0.3623945636235794,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}