{"id":"W2016524504","doi":"10.4161/chan.2.1.6007","title":"New insights into the therapeutic inhibition of voltage-gated sodium channels","year":2008,"lang":"en","type":"article","venue":"Channels","topic":"Ion channel regulation and function","field":"Biochemistry, Genetics and Molecular Biology","cited_by":19,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Chemistry; Sodium channel; Population; Inhibitory postsynaptic potential; Gene isoform; Depolarization; Pharmacology; Protonation; Biophysics; Membrane potential; Stereochemistry; Biochemistry; Sodium; Biology; Neuroscience; Medicine","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0007951119,0.0006950473,0.0008395235,0.0007044428,0.000275213,0.001606894,0.0009382541,0.001254071,0.007498669],"category_scores_gemma":[0.0005704635,0.0002890288,0.0006054672,0.0004494444,0.0009017703,0.002016375,0.0006608341,0.002905877,0.001198709],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006757746,"about_ca_system_score_gemma":0.000648558,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004596254,"about_ca_topic_score_gemma":0.0009346415,"domain_scores_codex":[0.999687,0.00006143909,0.00001880582,0.00004718143,0.0001018679,0.00008375652],"domain_scores_gemma":[0.9997953,0.00007063302,0.00002764262,0.00001370591,0.00005193263,0.00004083339],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.0009989515,0.001005365,0.000938984,0.005269185,0.0001783118,0.001683803,0.0004659679,0.003428418,0.1341136,0.1355776,0.04088547,0.6754544],"study_design_scores_gemma":[0.0004079517,0.002374163,0.001953977,0.001241146,0.0001647005,0.002723945,0.0003959658,0.005059862,0.02533724,0.06173971,0.8985109,0.00009039607],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.02916191,0.8623614,0.02301641,0.02604596,0.003718067,0.0002122889,0.0008199391,0.000445891,0.05421822],"genre_scores_gemma":[0.1806749,0.7698281,0.01906883,0.01163347,0.004007034,0.0001902465,0.0006295536,0.00009750154,0.0138703],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.007498669,"threshold_uncertainty_score":0.02508557,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02190508288709671,"score_gpt":0.2388304637938939,"score_spread":0.2169253809067972,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}