{"id":"W2016545633","doi":"10.1097/fpc.0b013e3282f3606e","title":"A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent","year":2008,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research","keywords":"CYP2A6; Pharmacogenetics; Allele; In vivo; Genetics; Allele frequency; Biology; Population; Descent (aeronautics); Enzyme; In vitro; Gene; Medicine; Genotype; Geography; Environmental health; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0007162486,0.0003645728,0.0005418863,0.0005365601,0.0001181192,0.00001993613,0.00014006,0.0002378319,0.00003992332],"category_scores_gemma":[0.00003895063,0.0004084787,0.00005768513,0.0003874873,0.0002845728,0.00009584525,0.0001883254,0.0005045658,8.774518e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00009867787,"about_ca_system_score_gemma":0.00009051122,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004281043,"about_ca_topic_score_gemma":0.0002514415,"domain_scores_codex":[0.9977018,0.0002417385,0.0007847413,0.0005414682,0.0001692348,0.0005610273],"domain_scores_gemma":[0.9990418,0.0002012793,0.0002308283,0.0001360367,0.0000578908,0.0003321547],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001642889,0.0005997171,0.2209877,0.0001082707,0.00008406767,0.0000458437,0.002058941,0.004397042,0.7571039,0.00005907637,0.00003787249,0.01287472],"study_design_scores_gemma":[0.01652027,0.0001882407,0.4941722,0.00004994132,0.0003828981,0.0001950971,0.0004150634,0.1369979,0.3377341,0.0008319186,0.01149836,0.00101399],"study_design_candidate":"bench_or_experimental","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9884003,0.01017461,0.0001427995,0.000120491,0.0002740572,0.0006288876,0.0001202065,0.00001563202,0.0001230407],"genre_scores_gemma":[0.970326,0.02832605,0.0005641708,0.0005445759,0.0001032459,0.00003719448,0.00003444736,0.00004180927,0.00002249775],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.4193698,"threshold_uncertainty_score":0.9998367,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0661402791490691,"score_gpt":0.3448930301354703,"score_spread":0.2787527509864012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}