{"id":"W2016545633","doi":"10.1097/fpc.0b013e3282f3606e","title":"A novel CYP2A6 allele, CYP2A6*23, impairs enzyme function in vitro and in vivo and decreases smoking in a population of Black-African descent","year":2008,"lang":"en","type":"article","venue":"Pharmacogenetics and Genomics","topic":"Pharmacogenetics and Drug Metabolism","field":"Pharmacology, Toxicology and Pharmaceutics","cited_by":63,"is_retracted":false,"has_abstract":true,"ca_institutions":"Canada Research Chairs; University of Toronto; Centre for Addiction and Mental Health","funders":"Canadian Institutes of Health Research","keywords":"CYP2A6; Pharmacogenetics; Allele; In vivo; Genetics; Allele frequency; Biology; Population; Descent (aeronautics); Enzyme; In vitro; Gene; Medicine; Genotype; Geography; Environmental health; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002952917,0.0004176312,0.0003432508,0.0002036921,0.0001818651,0.0001889655,0.0001469826,0.0003236046,0.002074675],"category_scores_gemma":[0.0004969995,0.0000921471,0.0002545058,0.0002133932,0.0002000512,0.00006644503,0.0001001694,0.0003852355,0.0002672909],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001474357,"about_ca_system_score_gemma":0.0001464151,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001120637,"about_ca_topic_score_gemma":0.001044247,"domain_scores_codex":[0.9997725,0.00006019594,0.00001385195,0.00007172591,0.00005619902,0.00002547899],"domain_scores_gemma":[0.9997112,0.00004536752,0.0001434936,0.00002100752,0.0000219224,0.00005697377],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"observational","study_design_scores_codex":[0.001405216,0.0003162494,0.06235177,0.0000758512,0.0001982861,0.0007435889,0.0000951545,0.0001196105,0.9244725,0.00008952349,0.0002295627,0.009902664],"study_design_scores_gemma":[0.0002648547,0.005000834,0.7132488,0.00004068086,0.0004725384,0.01883952,0.0001416177,0.001870718,0.255208,0.0001535678,0.004726811,0.00003199131],"study_design_candidate":"observational","study_design_consensus":null,"genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9988999,0.000260936,0.0005192714,0.0000393481,0.000009228655,0.000009385884,0.00010494,0.00001692786,0.0001399375],"genre_scores_gemma":[0.9977029,0.0002350007,0.001149711,0.00004625381,0.00001412266,0.00001591568,0.0002375106,0.00001432387,0.0005842641],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002074675,"threshold_uncertainty_score":0.006940544,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0661402791490691,"score_gpt":0.3448930301354703,"score_spread":0.2787527509864012,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}