{"id":"W2016558849","doi":"10.1124/dmd.109.027706","title":"Glucuronidation of the Antiretroviral Drug Efavirenz by UGT2B7 and an in Vitro Investigation of Drug-Drug Interaction with Zidovudine","year":2009,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":145,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"National Institute of Allergy and Infectious Diseases; Center for AIDS Research, University of Washington; Case Western Reserve University; National Institutes of Health; School of Medicine, Case Western Reserve University; Université Laval","keywords":"Glucuronidation; UGT2B7; Efavirenz; Zidovudine; Microsome; Glucuronide; Chemistry; Metabolite; Reverse-transcriptase inhibitor; Pharmacology; Enzyme; Biochemistry; Biology; Reverse transcriptase; Virology; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0005558517,0.000580636,0.0005996587,0.0005608096,0.000578329,0.0006062181,0.0004178568,0.0005426805,0.001263265],"category_scores_gemma":[0.0007061219,0.000386828,0.001065876,0.0004752537,0.000316239,0.0003313721,0.0002458988,0.0007514653,0.000359358],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000773953,"about_ca_system_score_gemma":0.0004759055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.007553633,"about_ca_topic_score_gemma":0.006511126,"domain_scores_codex":[0.9991142,0.0005405062,0.00003549767,0.00006583241,0.0001108419,0.0001330323],"domain_scores_gemma":[0.9997488,0.0001226069,0.00003038692,0.00003004992,0.00004065653,0.00002752958],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.005085174,0.001163843,0.00876595,0.0003266992,0.0003884462,0.001025595,0.0003055219,0.004169298,0.9566035,0.001515568,0.0007570737,0.01989339],"study_design_scores_gemma":[0.0002334654,0.007217539,0.01958982,0.00002469316,0.0002420626,0.001635809,0.0001710388,0.01478686,0.9521803,0.0001658297,0.003700597,0.00005189301],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9955963,0.002204494,0.0007142668,0.00008227502,0.00002151342,0.00002657098,0.0001971139,0.00001100976,0.001146432],"genre_scores_gemma":[0.9951035,0.001646631,0.001269539,0.00003111759,0.00002300076,0.00001545425,0.0006579355,0.0000156855,0.001237151],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.007553633,"threshold_uncertainty_score":0.01501936,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004912873872026827,"score_gpt":0.2321590014846999,"score_spread":0.2272461276126731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}