{"id":"W2016558849","doi":"10.1124/dmd.109.027706","title":"Glucuronidation of the Antiretroviral Drug Efavirenz by UGT2B7 and an in Vitro Investigation of Drug-Drug Interaction with Zidovudine","year":2009,"lang":"en","type":"article","venue":"Drug Metabolism and Disposition","topic":"HIV/AIDS drug development and treatment","field":"Medicine","cited_by":145,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université Laval; Centre hospitalier universitaire de Québec","funders":"National Institute of Allergy and Infectious Diseases; Center for AIDS Research, University of Washington; Case Western Reserve University; National Institutes of Health; School of Medicine, Case Western Reserve University; Université Laval","keywords":"Glucuronidation; UGT2B7; Efavirenz; Zidovudine; Microsome; Glucuronide; Chemistry; Metabolite; Reverse-transcriptase inhibitor; Pharmacology; Enzyme; Biochemistry; Biology; Reverse transcriptase; Virology; Human immunodeficiency virus (HIV)","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002459567,0.0001875083,0.0003401049,0.0001778016,0.00007906178,0.00002215972,0.00004816291,0.00003795254,0.000005291834],"category_scores_gemma":[0.00001308902,0.0001277673,0.00003936857,0.0003074261,0.0001118828,0.0005300167,0.00001860292,0.000122403,7.594891e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003704012,"about_ca_system_score_gemma":0.00004333055,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0002311471,"about_ca_topic_score_gemma":0.00005327387,"domain_scores_codex":[0.998826,0.0001315009,0.0003569958,0.0002671242,0.0002715506,0.0001468119],"domain_scores_gemma":[0.9993961,0.00003043231,0.000233086,0.0001772705,0.00007515629,0.00008795821],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.002176553,0.0009484891,0.1813681,0.0002670735,0.0001122698,0.000007498231,0.0190038,0.00001368748,0.7461393,0.001504751,0.001384748,0.04707363],"study_design_scores_gemma":[0.003195652,0.00007517525,0.4755801,0.0002480277,0.0002910878,0.00001252615,0.000935692,0.0003740094,0.5186058,0.0003408534,0.0001786086,0.0001624756],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9963115,0.0008449748,0.00003054643,0.002082067,0.0000710266,0.0004487356,0.00003170829,0.0000195969,0.0001598009],"genre_scores_gemma":[0.9981461,0.0001856092,0.000531224,0.0001355075,0.00004922716,0.0000138043,0.0005036397,0.00001177909,0.0004231004],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.294212,"threshold_uncertainty_score":0.5210198,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.004912873872026827,"score_gpt":0.2321590014846999,"score_spread":0.2272461276126731,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}