{"id":"W2016583186","doi":"10.1016/j.biochi.2011.03.006","title":"Binding of antitumor tamoxifen and its metabolites 4-hydroxytamoxifen and endoxifen to human serum albumin","year":2011,"lang":"en","type":"article","venue":"Biochimie","topic":"Protein Interaction Studies and Fluorescence Analysis","field":"Biochemistry, Genetics and Molecular Biology","cited_by":93,"is_retracted":false,"has_abstract":false,"ca_institutions":"Université du Québec à Trois-Rivières","funders":"Natural Sciences and Engineering Research Council of Canada","keywords":"Human serum albumin; Tamoxifen; Chemistry; Circular dichroism; Albumin; Plasma protein binding; Binding constant; Serum albumin; Biochemistry; Binding site; Stereochemistry; Biology; Cancer","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0002997523,0.0002927769,0.0002936653,0.0002430272,0.0002739522,0.0002818478,0.0004390261,0.0003323086,0.001387819],"category_scores_gemma":[0.0005062162,0.0001779396,0.0003070628,0.0002369891,0.0002099896,0.0001827431,0.0001808783,0.0002695503,0.0004183261],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0006332325,"about_ca_system_score_gemma":0.000287971,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.004861171,"about_ca_topic_score_gemma":0.002860681,"domain_scores_codex":[0.9997212,0.00008438179,0.00001317679,0.0000475076,0.00005415541,0.00007948413],"domain_scores_gemma":[0.9998467,0.00007015945,0.00001852354,0.00001308915,0.00002807233,0.00002341283],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001491481,0.00006879495,0.001334956,0.00008185302,0.00004794018,0.0001278158,0.0001023314,0.0007079814,0.9918321,0.0004373189,0.0001909037,0.003576615],"study_design_scores_gemma":[0.00003221507,0.0003338715,0.005562596,0.000004682567,0.00001754204,0.0001300544,0.00006685368,0.004207903,0.9872688,0.00007204657,0.002292961,0.00001040765],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9944347,0.001480303,0.00270383,0.00009130927,0.00001973354,0.000009267729,0.00008692558,0.00003227581,0.001141723],"genre_scores_gemma":[0.9958818,0.0003538018,0.0007705872,0.00003197288,0.000007326602,0.000008376791,0.0002858678,0.00001116784,0.002649052],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.004861171,"threshold_uncertainty_score":0.009665787,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02687119092786097,"score_gpt":0.2672026770483232,"score_spread":0.2403314861204623,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}