{"id":"W2016613054","doi":"10.1242/jcs.025957","title":"LC3-mediated fibronectin mRNA translation induces fibrosarcoma growth by increasing connective tissue growth factor","year":2009,"lang":"en","type":"article","venue":"Journal of Cell Science","topic":"Connective Tissue Growth Factor Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":14,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"National Heart, Lung, and Blood Institute","keywords":"HT1080; CTGF; Fibronectin; Fibrosarcoma; Biology; Molecular biology; Transfection; Connective tissue; Growth factor; Messenger RNA; Cell biology; Cell culture; Gene; Extracellular matrix; Biochemistry; Receptor","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001482444,0.0003169994,0.0001926166,0.000183725,0.0001743703,0.0001907131,0.0000884601,0.0001554842,0.001329143],"category_scores_gemma":[0.0001334659,0.00009915216,0.0002186332,0.0001343696,0.0001919744,0.00008258815,0.0001563773,0.0004049444,0.0003295609],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004858683,"about_ca_system_score_gemma":0.0002437757,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001619523,"about_ca_topic_score_gemma":0.003381759,"domain_scores_codex":[0.9998832,0.00002099445,0.000009780588,0.00001815433,0.00003739584,0.00003044275],"domain_scores_gemma":[0.999858,0.00003998975,0.000032171,0.00001716808,0.00002002773,0.00003260608],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00002638949,0.000009274684,0.00004488759,0.00001157732,0.000001068105,0.0000150859,0.000005967133,0.00001460246,0.9995553,0.00002105808,0.00002423743,0.0002706312],"study_design_scores_gemma":[0.00000686079,0.0001040874,0.001371599,0.000002176938,0.000004491258,0.00006275814,0.000006383492,0.0004338351,0.9971418,0.00001495876,0.0008490265,0.000001910566],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9925512,0.001322403,0.003079766,0.0001431343,0.00004434054,0.0000504712,0.0004242306,0.0001732022,0.002211283],"genre_scores_gemma":[0.9904766,0.0006924571,0.004406984,0.0001116971,0.00002420822,0.00005582658,0.0008604691,0.00006758489,0.00330415],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001619523,"threshold_uncertainty_score":0.004446447,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0162613187742888,"score_gpt":0.2887794629716575,"score_spread":0.2725181441973688,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}