{"id":"W2016656923","doi":"10.1074/jbc.m111.218990","title":"Structure and Biochemical Functions of SIRT6","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":312,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Canadian Institutes of Health Research; National Institute of General Medical Sciences; Wellcome Trust","keywords":"NAD+ kinase; Sirtuin; SIRT2; Biochemistry; Histone deacetylase; Histone; Isothermal titration calorimetry; Acetylation; Ribose; Chemistry; Binding site; Biology; Stereochemistry; Enzyme; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001687015,0.0006892669,0.0003792739,0.0002260092,0.000441442,0.0007650469,0.0007094909,0.0007856173,0.002602045],"category_scores_gemma":[0.0002829808,0.0002403503,0.0006463284,0.0004549866,0.0003346743,0.0005170013,0.0002741646,0.001033289,0.001921425],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0009451084,"about_ca_system_score_gemma":0.0003300577,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001216091,"about_ca_topic_score_gemma":0.0009013733,"domain_scores_codex":[0.9998491,0.00002011533,0.000008001198,0.00004801946,0.00005353199,0.00002123355],"domain_scores_gemma":[0.9998966,0.000008560151,0.00002061538,0.00001189496,0.00002865402,0.00003366738],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0008998332,0.0001638085,0.003076297,0.0008707687,0.000083297,0.0005647434,0.00020262,0.008562943,0.9290752,0.01346724,0.004531637,0.0385016],"study_design_scores_gemma":[0.0001551631,0.0005863567,0.007423658,0.00006530987,0.00008856731,0.001314188,0.0001568173,0.02635314,0.7282919,0.006111111,0.229333,0.0001207903],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.8395492,0.05970177,0.04699536,0.003130223,0.001574367,0.0001143452,0.005213826,0.001512314,0.0422085],"genre_scores_gemma":[0.9272436,0.01700418,0.02647542,0.0004516062,0.0002299871,0.00003490972,0.01147046,0.0001219304,0.01696781],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002602045,"threshold_uncertainty_score":0.008704722,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03099533830803228,"score_gpt":0.2569174234893089,"score_spread":0.2259220851812766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}