{"id":"W2016656923","doi":"10.1074/jbc.m111.218990","title":"Structure and Biochemical Functions of SIRT6","year":2011,"lang":"en","type":"article","venue":"Journal of Biological Chemistry","topic":"Sirtuins and Resveratrol in Medicine","field":"Medicine","cited_by":312,"is_retracted":false,"has_abstract":true,"ca_institutions":"Structural Genomics Consortium; University of Toronto","funders":"Canadian Institutes of Health Research; National Institute of General Medical Sciences; Wellcome Trust","keywords":"NAD+ kinase; Sirtuin; SIRT2; Biochemistry; Histone deacetylase; Histone; Isothermal titration calorimetry; Acetylation; Ribose; Chemistry; Binding site; Biology; Stereochemistry; Enzyme; DNA","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["insufficient_payload"],"consensus_categories":[],"category_scores_codex":[0.0001019638,0.00007866899,0.0002926178,0.00001953364,0.00001530583,0.000001485366,0.0000559633,0.0001879186,0.001071919],"category_scores_gemma":[0.0002357357,0.00004056994,0.00008990439,0.00006339687,0.0002248642,0.00001314452,0.00002373152,0.0003048033,3.311006e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001067837,"about_ca_system_score_gemma":0.00002777803,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000001328044,"about_ca_topic_score_gemma":2.441819e-8,"domain_scores_codex":[0.9993996,0.000008623197,0.0003028616,0.0000804711,0.00011807,0.00009039536],"domain_scores_gemma":[0.9994214,0.00003565062,0.0001695812,0.00008501382,0.0001374192,0.0001508885],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0003431081,0.0001046118,0.05426197,0.00005498024,0.00006993397,0.00005296094,0.00003865778,6.245273e-8,0.9434525,0.000004212584,0.001028032,0.0005889302],"study_design_scores_gemma":[0.001406018,0.0008560155,0.05418151,0.0001208304,0.0001278787,0.002287767,0.0003558433,0.000006439131,0.9390768,0.0002737394,0.00123497,0.00007222395],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.996594,0.00149551,0.00003891189,0.0001625357,0.00006661359,0.00002619667,0.000007534608,0.000004249461,0.001604487],"genre_scores_gemma":[0.9982317,0.0001894311,0.001021461,0.00008746549,0.0003546424,2.19441e-7,0.00000496199,0.000003357069,0.0001067647],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00437577,"threshold_uncertainty_score":0.9998412,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03099533830803228,"score_gpt":0.2569174234893089,"score_spread":0.2259220851812766,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}