{"id":"W2016670516","doi":"10.1016/j.febslet.2004.07.069","title":"Aminoethyl benzenesulfonyl fluoride and its hexapeptide (Ac‐VFRSLK) conjugate are both in vitro inhibitors of subtilisin kexin isozyme‐1","year":2004,"lang":"en","type":"article","venue":"FEBS Letters","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":16,"is_retracted":false,"has_abstract":true,"ca_institutions":"","funders":"Ottawa Hospital Research Institute; Canadian Institutes of Health Research; Ontario Innovation Trust","keywords":"Subtilisin; Conjugate; In vitro; Chemistry; Isozyme; Biochemistry; Fluoride; Enzyme; Stereochemistry; Mathematics","routes":{"ca_aff":false,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":true},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003678353,0.0002655515,0.0003049832,0.0001709099,0.00005576339,0.00002297083,0.0002646265,0.000166527,0.00001343138],"category_scores_gemma":[0.00008584817,0.000253171,0.0001029622,0.0001908882,0.0001760047,0.0000131839,0.0001419891,0.0001819036,0.0000129026],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006652217,"about_ca_system_score_gemma":0.00008897008,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0000897752,"about_ca_topic_score_gemma":0.0003245805,"domain_scores_codex":[0.9981714,0.0001255616,0.0003839575,0.0005383935,0.0002703186,0.0005104027],"domain_scores_gemma":[0.9992311,0.00003137275,0.0001423556,0.0003998081,0.00005958296,0.0001357577],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.001717714,0.00005728892,0.001902504,0.00004397324,0.00004246895,0.00003760211,0.00008874941,0.0002321962,0.9944468,0.000008530746,0.0004081523,0.001014035],"study_design_scores_gemma":[0.002263495,0.0005132987,0.003841883,0.000073186,0.000007843595,0.000009849204,0.00005514069,0.000009841175,0.9921242,0.0000410957,0.0007857786,0.0002743746],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9942683,0.001557601,0.00005830244,0.003556395,0.00009948703,0.0003177863,0.00007722167,0.00001569654,0.00004923743],"genre_scores_gemma":[0.9970349,0.0002764484,0.0001356042,0.002113553,0.00021469,0.00002967948,0.00005146654,0.00005070991,0.00009292551],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00276665,"threshold_uncertainty_score":0.9999921,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01211323551657504,"score_gpt":0.253311252161796,"score_spread":0.241198016645221,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}