{"id":"W2016680950","doi":"10.1371/journal.pgen.1003957","title":"Oct4 Is Required ∼E7.5 for Proliferation in the Primitive Streak","year":2013,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Biology; Primitive streak; Cell biology; SOX2; Embryonic stem cell; Inner cell mass; Cre recombinase; Somite; Induced pluripotent stem cell; Genetics; Epiblast; Embryo; Molecular biology; Embryogenesis; Transgene; Genetically modified mouse; Blastocyst; Gastrulation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001189614,0.0002700002,0.0002182314,0.0002749114,0.0002129911,0.0004447058,0.0002734801,0.0002774169,0.002092314],"category_scores_gemma":[0.0001973517,0.0003123411,0.0001824047,0.0001337988,0.0002483478,0.0002201389,0.00035976,0.000532016,0.001114758],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0003503745,"about_ca_system_score_gemma":0.0004554309,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001635927,"about_ca_topic_score_gemma":0.002426001,"domain_scores_codex":[0.9998252,0.0000185317,0.00001789335,0.00002849169,0.00007270892,0.00003718702],"domain_scores_gemma":[0.9996488,0.000037993,0.0001230011,0.00002851646,0.00004190317,0.0001197379],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00005690602,0.000005860743,0.0003759692,0.00002016363,0.000001846865,0.00009603675,0.000007511333,0.00003114778,0.9986311,0.000104311,0.0000239585,0.0006451225],"study_design_scores_gemma":[0.0000203069,0.0001086779,0.03946482,0.00001777238,0.0000143353,0.0006596406,0.00004830242,0.0007271581,0.9521846,0.000115865,0.006631802,0.000006761918],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.988627,0.001919196,0.003577124,0.0001180709,0.00003440022,0.00002660655,0.001227049,0.0001581552,0.004312394],"genre_scores_gemma":[0.9821361,0.001095227,0.002903313,0.0000990207,0.00001081155,0.00003684766,0.003013897,0.00009197331,0.0106128],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.002092314,"threshold_uncertainty_score":0.006999433,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03236824132809311,"score_gpt":0.284267283826717,"score_spread":0.2518990424986238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}