{"id":"W2016680950","doi":"10.1371/journal.pgen.1003957","title":"Oct4 Is Required ∼E7.5 for Proliferation in the Primitive Streak","year":2013,"lang":"en","type":"article","venue":"PLoS Genetics","topic":"Pluripotent Stem Cells Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":83,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Toronto","funders":"Canadian Institutes of Health Research","keywords":"Biology; Primitive streak; Cell biology; SOX2; Embryonic stem cell; Inner cell mass; Cre recombinase; Somite; Induced pluripotent stem cell; Genetics; Epiblast; Embryo; Molecular biology; Embryogenesis; Transgene; Genetically modified mouse; Blastocyst; Gastrulation","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001488753,0.0001163574,0.00009255587,0.00003466506,0.00006500664,0.00005693452,0.0002737962,0.0001211994,0.00002329382],"category_scores_gemma":[0.00008241933,0.00008916453,0.00005183286,0.00007904542,0.00005142244,0.000004045205,0.00007294431,0.00007241124,0.00004242142],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00001624086,"about_ca_system_score_gemma":0.00007092327,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005444839,"about_ca_topic_score_gemma":0.00002672418,"domain_scores_codex":[0.9989541,0.00008401326,0.0001816024,0.0002793571,0.0002114868,0.0002894751],"domain_scores_gemma":[0.9993494,0.00003040393,0.00004568922,0.0003544209,0.0001735077,0.00004653872],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00003799388,0.0001652117,0.003227425,0.00004353383,0.00003759131,9.073364e-7,0.0003362139,0.00003907665,0.9870681,0.00003189656,0.007178161,0.001833859],"study_design_scores_gemma":[0.0005887522,0.0004016141,0.003372034,0.00001142129,0.00001431992,0.000003226511,0.0001949812,0.005117709,0.9818844,0.0002881239,0.0079709,0.000152572],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9950982,0.0004055482,0.0003306849,0.001174955,0.00003330714,0.001608695,0.00003439088,0.000005866889,0.001308354],"genre_scores_gemma":[0.9967637,0.0001799552,0.0008089344,0.0006785013,0.0001917834,0.0005157468,0.000142936,0.00002121456,0.000697247],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.005183785,"threshold_uncertainty_score":0.3636024,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.03236824132809311,"score_gpt":0.284267283826717,"score_spread":0.2518990424986238,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}