{"id":"W2016686236","doi":"10.1002/jbmr.461","title":"Parathyroid hormone signaling via Gαs is selectively inhibited by an NH2-terminally truncated Gαs: Implications for pseudohypoparathyroidism","year":2011,"lang":"en","type":"article","venue":"Journal of Bone and Mineral Research","topic":"Genetic Syndromes and Imprinting","field":"Biochemistry, Genetics and Molecular Biology","cited_by":42,"is_retracted":false,"has_abstract":true,"ca_institutions":"Royal Victoria Regional Health Centre; Royal Victoria Hospital; Victoria Hospital; McGill University","funders":"National Institute of Diabetes and Digestive and Kidney Diseases; Canadian Institutes of Health Research","keywords":"Pseudohypoparathyroidism; Internal medicine; Endocrinology; Parathyroid hormone; Parathyroid hormone receptor; Gs alpha subunit; GNAS complex locus; Receptor; Chemistry; Calcitonin; G protein; Biology; Hormone receptor; Medicine; Calcium; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.000144477,0.0003052829,0.0002124546,0.00009717265,0.00008846406,0.0002707867,0.0002542075,0.0003088888,0.0007200388],"category_scores_gemma":[0.0001525049,0.00009992813,0.0003275827,0.0001012252,0.0004370289,0.0001495169,0.0001553315,0.0005014101,0.0002242925],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.000260739,"about_ca_system_score_gemma":0.0001349046,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004216609,"about_ca_topic_score_gemma":0.00043869,"domain_scores_codex":[0.9999158,0.00001926237,0.000008649807,0.00001610539,0.00002033922,0.00001971209],"domain_scores_gemma":[0.9999301,0.00001506047,0.00002309908,0.000009793246,0.000005183086,0.00001669867],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.000226377,0.00001065305,0.000352967,0.00001974068,0.000007187085,0.0001915059,0.000008210272,0.00007577235,0.9982494,0.0001599271,0.00002655546,0.0006718413],"study_design_scores_gemma":[0.000253206,0.001894848,0.02310048,0.00001738524,0.00009118103,0.006058985,0.0001061463,0.002391534,0.9563478,0.0003380037,0.009385025,0.00001535804],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9962788,0.001493431,0.001093439,0.0002485679,0.00003054154,0.0000138182,0.0001106315,0.00003956805,0.0006912208],"genre_scores_gemma":[0.9969747,0.00113427,0.0009909213,0.0001453822,0.00001400288,0.00001277418,0.0001884495,0.00001010207,0.0005293089],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.0007200388,"threshold_uncertainty_score":0.002408743,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06707259939033473,"score_gpt":0.3436808591795755,"score_spread":0.2766082597892408,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}