{"id":"W2016693473","doi":"10.1016/j.ymthe.2006.08.029","title":"18. Comparison of Antitumor Activity of Cytosine Deaminase::Uracil Phosphoribosyl Transferase (CD::UPRT) and Purine Nucleoside Phosphorylase (PNP) Suicide Genes Using Replicative but Non-Disseminative Adenovirus Vectors","year":2006,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institut National de la Recherche Scientifique; Université du Québec à Montréal; McGill University; Montreal Neurological Institute and Hospital; Biotechnology Research Institute","funders":"","keywords":"Cytosine deaminase; Suicide gene; Biology; Expression cassette; Oncolytic virus; Oncolytic adenovirus; Viral vector; Gene; Genetic enhancement; Virology; Molecular biology; Internal ribosome entry site; Adenoviridae; Vector (molecular biology); Virus; Genetics; RNA; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0003399779,0.0003664164,0.0005034764,0.0005016281,0.0000903231,0.0003535227,0.0002279555,0.000387901,0.001339883],"category_scores_gemma":[0.0002184602,0.0001156535,0.0004169285,0.0003418335,0.0001473393,0.0002674724,0.0001608501,0.0005559505,0.0002757561],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002402909,"about_ca_system_score_gemma":0.0001965798,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0005665419,"about_ca_topic_score_gemma":0.0003687177,"domain_scores_codex":[0.9996674,0.00006883683,0.00005011431,0.00004201848,0.0001033861,0.00006809081],"domain_scores_gemma":[0.9996624,0.0001186657,0.0000468216,0.0000275011,0.00007553737,0.00006905768],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007542575,0.0002940941,0.0004216735,0.0001356647,0.0000245635,0.00003233522,0.00002899066,0.0003106188,0.991244,0.000124905,0.00008322222,0.006545763],"study_design_scores_gemma":[0.00004253787,0.003150147,0.002120969,0.000006138638,0.00003322329,0.00009866828,0.00001074006,0.0009355624,0.9923488,0.00002321745,0.001226171,0.00000385271],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9933397,0.003129028,0.001471417,0.00004447182,0.00004615213,0.00003709337,0.0004004785,0.00004017008,0.001491436],"genre_scores_gemma":[0.9899968,0.001756641,0.00286983,0.00002597734,0.00002798108,0.0000700184,0.001591311,0.00002604144,0.00363541],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001339883,"threshold_uncertainty_score":0.004482329,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02582772028858154,"score_gpt":0.3276625989329841,"score_spread":0.3018348786444025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}