{"id":"W2016693473","doi":"10.1016/j.ymthe.2006.08.029","title":"18. Comparison of Antitumor Activity of Cytosine Deaminase::Uracil Phosphoribosyl Transferase (CD::UPRT) and Purine Nucleoside Phosphorylase (PNP) Suicide Genes Using Replicative but Non-Disseminative Adenovirus Vectors","year":2006,"lang":"en","type":"article","venue":"Molecular Therapy","topic":"Virus-based gene therapy research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"Université de Montréal; Institut National de la Recherche Scientifique; Université du Québec à Montréal; McGill University; Montreal Neurological Institute and Hospital; Biotechnology Research Institute","funders":"","keywords":"Cytosine deaminase; Suicide gene; Biology; Expression cassette; Oncolytic virus; Oncolytic adenovirus; Viral vector; Gene; Genetic enhancement; Virology; Molecular biology; Internal ribosome entry site; Adenoviridae; Vector (molecular biology); Virus; Genetics; RNA; Recombinant DNA","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":["metaepi_narrow"],"consensus_categories":[],"category_scores_codex":[0.0003920464,0.0004920033,0.0007328572,0.0001692108,0.0001505504,0.00002992467,0.0003907713,0.0002326303,0.00004163774],"category_scores_gemma":[0.00004431138,0.0004906815,0.0002532776,0.000407139,0.0005442936,0.00001948737,0.0001004399,0.0002348243,0.000001850265],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00006416872,"about_ca_system_score_gemma":0.000188788,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001083078,"about_ca_topic_score_gemma":0.0002015616,"domain_scores_codex":[0.997321,0.0002572605,0.0005997799,0.0008182526,0.0004820578,0.000521667],"domain_scores_gemma":[0.9982148,0.00006037068,0.0003540639,0.0008555542,0.0003600096,0.0001551433],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.006301293,0.0008673016,0.00412438,0.00006872368,0.0002733518,0.00003847069,0.0001663863,0.0004544114,0.9733285,0.00001496188,0.00003660581,0.01432562],"study_design_scores_gemma":[0.002352717,0.00387755,0.006929596,0.00006124452,0.00005445323,0.00001766456,0.0001388946,0.0005247795,0.9853812,0.00004034762,0.0001646419,0.0004568587],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.976294,0.01976277,0.002731252,0.00004855426,0.00004299032,0.0008224538,0.0002204267,0.00001926532,0.0000582579],"genre_scores_gemma":[0.9972553,0.001504186,0.0007831281,0.00003463593,0.00008258264,0.00005177289,0.0001186788,0.0001022025,0.0000675431],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.02096124,"threshold_uncertainty_score":0.9997545,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.02582772028858154,"score_gpt":0.3276625989329841,"score_spread":0.3018348786444025,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}