{"id":"W2016728727","doi":"10.1186/1742-2094-9-64","title":"A novel anti-EMMPRIN function-blocking antibody reduces T cell proliferation and neurotoxicity: relevance to multiple sclerosis","year":2012,"lang":"en","type":"article","venue":"Journal of Neuroinflammation","topic":"Signaling Pathways in Disease","field":"Biochemistry, Genetics and Molecular Biology","cited_by":38,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Calgary","funders":"Canadian Institutes of Health Research","keywords":"Basigin; clone (Java method); Monoclonal antibody; Experimental autoimmune encephalomyelitis; T cell; Immunology; Multiple sclerosis; Blocking antibody; Matrix metalloproteinase; Antibody; Biology; Chemistry; Molecular biology; Immune system; Biochemistry","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0001578758,0.0005480659,0.0002821877,0.0002566286,0.0001225242,0.0001994813,0.0004127436,0.0005284499,0.001050623],"category_scores_gemma":[0.000141697,0.0001238102,0.0002820249,0.0001234435,0.0001624863,0.000144736,0.0001192757,0.0007223468,0.0003498136],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0004080097,"about_ca_system_score_gemma":0.0003307337,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0004826834,"about_ca_topic_score_gemma":0.0008917434,"domain_scores_codex":[0.9998778,0.00001309624,0.00001177382,0.00002798294,0.00003214513,0.00003707229],"domain_scores_gemma":[0.9999013,0.00001496021,0.00002760656,0.000007751624,0.00001955039,0.00002883623],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001008521,0.0001404053,0.0001160103,0.00004426666,0.000007967857,0.00005900929,0.000004399039,0.00005021999,0.9970767,0.0000321653,0.00005033133,0.002317721],"study_design_scores_gemma":[0.0001349916,0.002032091,0.003367936,0.00001328358,0.00008290744,0.0008095708,0.000005802648,0.0005510718,0.9898074,0.0000200919,0.003170602,0.000004262874],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9905826,0.002455059,0.004867891,0.0001240467,0.00005240742,0.00008318525,0.0001489007,0.0001297381,0.001556139],"genre_scores_gemma":[0.9858559,0.002270905,0.007700578,0.0001855552,0.0000500219,0.0001341315,0.0007680855,0.00002254924,0.003012074],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001050623,"threshold_uncertainty_score":0.003514707,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.0291274342098382,"score_gpt":0.2556833052156182,"score_spread":0.22655587100578,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}