{"id":"W2016746408","doi":"10.1073/pnas.1409928111","title":"Immunization with a functional protein complex required for erythrocyte invasion protects against lethal malaria","year":2014,"lang":"en","type":"article","venue":"Proceedings of the National Academy of Sciences","topic":"Malaria Research and Control","field":"Medicine","cited_by":93,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of Victoria","funders":"National Institute of Allergy and Infectious Diseases; Canadian Institutes of Health Research; NHLBI Division of Intramural Research; National Institutes of Health; Division of Intramural Research, National Institute of Allergy and Infectious Diseases","keywords":"Plasmodium falciparum; Biology; Antibody; Virology; Malaria vaccine; Immunization; Malaria; Rhoptry; Antigen; Merozoite surface protein; Immunology; Apicomplexa","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.001700029,0.00009551503,0.0001891422,0.0001672695,0.0002703512,0.00002563622,0.0003043304,0.00007939935,0.00002186823],"category_scores_gemma":[0.001594502,0.00005640398,0.00006531036,0.0005542575,0.0005691606,0.0003096958,0.00007212811,0.0001645164,9.320699e-7],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00004374472,"about_ca_system_score_gemma":0.0001281921,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.00000405284,"about_ca_topic_score_gemma":1.153721e-7,"domain_scores_codex":[0.9979404,0.00001290785,0.0002640583,0.0002328082,0.001362599,0.0001872877],"domain_scores_gemma":[0.9986634,0.00009333115,0.0003276383,0.00001286117,0.0008464587,0.00005637074],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0007771439,0.00007051964,0.0006436851,0.0002345581,0.00002759861,6.030816e-9,0.00003267738,0.00005011394,0.8754596,0.1217179,0.0002943617,0.0006918826],"study_design_scores_gemma":[0.004618635,0.001375394,0.2126171,0.0007556218,0.00003693383,0.00003427245,0.000132988,0.03360007,0.7041202,0.04158809,0.0009352344,0.0001854669],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9523332,0.00003808588,0.0007025967,0.03520064,0.00001304639,0.003380308,0.00001535546,0.00003291149,0.008283868],"genre_scores_gemma":[0.9921705,0.000002157391,0.006899328,0.0003200988,0.0001296231,0.0001750658,0.000001963698,0.000006603448,0.0002947352],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.2119734,"threshold_uncertainty_score":0.2300088,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.06755486543037428,"score_gpt":0.3032576130931207,"score_spread":0.2357027476627464,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}