{"id":"W2016761742","doi":"10.1158/1538-7445.am2014-2988","title":"Abstract 2988: Microenvironmental distribution of trastuzumab is heterogeneous and decreases sharply when administered following a single dose of bevacizumab in Her2+ve xenografts and metastases models","year":2014,"lang":"en","type":"article","venue":"Cancer Research","topic":"Cancer, Hypoxia, and Metabolism","field":"Biochemistry, Genetics and Molecular Biology","cited_by":0,"is_retracted":false,"has_abstract":true,"ca_institutions":"University of British Columbia","funders":"","keywords":"Trastuzumab; Medicine; Context (archaeology); Distribution (mathematics); Bevacizumab; Tumor microenvironment; CD31; Pathology; Perfusion; Cancer; Cancer research; Breast cancer; Immunohistochemistry; Internal medicine; Chemotherapy; Biology","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.00006545353,0.0001785227,0.0002317262,0.000130864,0.00009328282,0.0001721991,0.00009527744,0.0001727176,0.001937931],"category_scores_gemma":[0.00005587933,0.0000876973,0.0001162875,0.0001025822,0.00009328673,0.0001275057,0.00008464969,0.0003992272,0.0003634821],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0002629845,"about_ca_system_score_gemma":0.0001359295,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.001315225,"about_ca_topic_score_gemma":0.001677641,"domain_scores_codex":[0.9999214,0.000006855289,0.000003699238,0.00001450911,0.00002929369,0.00002419221],"domain_scores_gemma":[0.999957,0.000004299627,0.00001118546,0.000003334346,0.000006477875,0.00001772794],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0001241718,0.00003337905,0.0001511412,0.000007810352,0.00000186786,0.00002283498,0.000004068887,0.0000250687,0.99888,0.00001199131,0.00006807827,0.0006696317],"study_design_scores_gemma":[0.00002578397,0.001015555,0.01003904,0.000003143888,0.00001072233,0.0003725796,0.00001893051,0.001263504,0.9855433,0.00002804317,0.00167599,0.000003651557],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9959658,0.000611256,0.001586196,0.00006690653,0.00001669283,0.00001875108,0.0003566229,0.00008655056,0.001290995],"genre_scores_gemma":[0.9928752,0.0002929353,0.001183621,0.00004314743,0.00000703699,0.00003989762,0.0008471769,0.00002800543,0.004682994],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.001937931,"threshold_uncertainty_score":0.006483018,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.04313930601089163,"score_gpt":0.3248451702347699,"score_spread":0.2817058642238783,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}