{"id":"W2016772355","doi":"10.1103/physrevlett.98.098105","title":"How <i>Xenopus Laevis</i> Replicates DNA Reliably even though Its Origins of Replication are Located and Initiated Stochastically","year":2007,"lang":"en","type":"article","venue":"Physical Review Letters","topic":"DNA Repair Mechanisms","field":"Biochemistry, Genetics and Molecular Biology","cited_by":41,"is_retracted":false,"has_abstract":true,"ca_institutions":"Simon Fraser University","funders":"","keywords":"Xenopus; Replication (statistics); DNA replication; Biology; Nucleation; Constraint (computer-aided design); Origin of replication; Origin recognition complex; Computer science; Cell biology; Physics; Replication timing; Cell division; Function (biology); Computational biology; DNA; Eukaryotic DNA replication; Cell; Genetics; Mathematics; Gene","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004183551,0.0002207568,0.0003875453,0.00002242465,0.00004000161,0.00001786626,0.0002165604,0.00004686077,0.000001687125],"category_scores_gemma":[0.0005616489,0.0001793083,0.0001217633,0.0002391063,0.00008050459,0.00001190393,0.0001081253,0.0001269264,0.000007132801],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.00003182118,"about_ca_system_score_gemma":0.00002019136,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.000005266621,"about_ca_topic_score_gemma":0.000002278395,"domain_scores_codex":[0.9984745,0.00007261362,0.0003166978,0.0006359045,0.0002145233,0.0002857356],"domain_scores_gemma":[0.9986107,0.00006272474,0.0002961939,0.0007274452,0.0001746543,0.0001282358],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.0000368242,0.00009015801,0.00005024401,0.0004547363,0.00004183961,0.000004028083,0.000007611925,0.000002838752,0.9960414,0.0004273548,0.0009890817,0.001853917],"study_design_scores_gemma":[0.0002573381,0.0002069095,0.0005896824,0.0006304196,0.0001155539,0.00001580829,0.000006277172,0.00009971827,0.96609,0.00007569168,0.03165023,0.000262324],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9824435,0.006403412,0.004312774,0.005944345,0.00004025373,0.0007122831,0.00003269353,0.00005102418,0.00005970179],"genre_scores_gemma":[0.9895149,0.002567287,0.0004806545,0.007024324,0.0001579564,0.00004950118,0.0001577079,0.00002682107,0.00002078622],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.03066114,"threshold_uncertainty_score":0.7311978,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.01943230471087748,"score_gpt":0.2901152930054885,"score_spread":0.270682988294611,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}