{"id":"W2016795443","doi":"10.1021/sb300092n","title":"Opportunities for Synthetic Biology in Antibiotics: Expanding Glycopeptide Chemical Diversity","year":2012,"lang":"en","type":"review","venue":"ACS Synthetic Biology","topic":"Microbial Natural Products and Biosynthesis","field":"Medicine","cited_by":57,"is_retracted":false,"has_abstract":true,"ca_institutions":"McMaster University","funders":"Natural Sciences and Engineering Research Council of Canada; Canadian Institutes of Health Research","keywords":"Glycopeptide; Synthetic biology; Antibiotic resistance; Antibiotics; Biology; Diversity (politics); Chemical biology; Computational biology; Biotechnology; Drug discovery; Drug development; Drug resistance; Antimicrobial; Drug; Microbiology; Bioinformatics; Genetics; Political science; Pharmacology","routes":{"ca_aff":true,"ca_fund":true,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"metacan-v3-hybrid-931329e0061c","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0006744894,0.0009212655,0.0008213198,0.001341499,0.0003879877,0.001173739,0.0006390297,0.001412365,0.002389093],"category_scores_gemma":[0.0004546451,0.000341952,0.0004609771,0.001368122,0.001244927,0.002485502,0.0008715803,0.002219573,0.00197179],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0008951694,"about_ca_system_score_gemma":0.0008337843,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0003877625,"about_ca_topic_score_gemma":0.0006740411,"domain_scores_codex":[0.9997614,0.00004972463,0.00002087021,0.00003345681,0.0001110426,0.00002346058],"domain_scores_gemma":[0.9997836,0.0001222467,0.00002696532,0.00001136412,0.00003508499,0.00002084368],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"design_other","study_design_gemma":"not_applicable","study_design_scores_codex":[0.00007507519,0.0001880122,0.0001774213,0.01355971,0.00007065089,0.0006114403,0.0002823096,0.001957582,0.03690055,0.08888476,0.02221798,0.8350744],"study_design_scores_gemma":[0.00001669728,0.0001182668,0.0001715836,0.0008444246,0.00001795291,0.001002521,0.0000866164,0.0002959438,0.006941531,0.01293318,0.9775476,0.00002362022],"study_design_candidate":"not_applicable","study_design_consensus":null,"genre_codex":"review","genre_gemma":"review","genre_scores_codex":[0.0006853693,0.9896662,0.00260875,0.00104968,0.000520493,0.0000120473,0.0000153273,0.00002387699,0.005418162],"genre_scores_gemma":[0.004212877,0.9907107,0.002405398,0.0004447125,0.0002966028,0.00001732945,0.00002117857,0.000006242159,0.001884946],"genre_candidate":"review","genre_consensus":"review","teacher_disagreement_score":0.002389093,"threshold_uncertainty_score":0.007992327,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.1583256874497932,"score_gpt":0.3482906396725031,"score_spread":0.1899649522227099,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}