{"id":"W2016806028","doi":"10.1038/sj.onc.1209819","title":"Farnesyltransferase and geranylgeranyltransferase I inhibitors upregulate RhoB expression by HDAC1 dissociation, HAT association and histone acetylation of the RhoB promoter","year":2006,"lang":"en","type":"article","venue":"Oncogene","topic":"Histone Deacetylase Inhibitors Research","field":"Biochemistry, Genetics and Molecular Biology","cited_by":60,"is_retracted":false,"has_abstract":false,"ca_institutions":"University of British Columbia","funders":"","keywords":"RHOB; Farnesyltransferase; Biology; Acetylation; HDAC1; Histone; Downregulation and upregulation; Cancer research; Genetics; Gene; Histone deacetylase; Biochemistry; Enzyme; Prenylation","routes":{"ca_aff":true,"ca_fund":false,"ca_venue":false,"about_ca":false,"invisible_to_affiliation_only":false},"retraction":null,"screen":null,"direct_labels":[],"prediction":{"model_version":"codex-gemma-dda1882f352a","candidate_categories":[],"consensus_categories":[],"category_scores_codex":[0.0004366833,0.0002174318,0.000228764,0.00005316936,0.0002491164,0.00003849256,0.0001157214,0.0003064234,0.00001549034],"category_scores_gemma":[0.00009750411,0.0001832258,0.000101068,0.0001598554,0.0001456207,0.00002222811,0.00006045883,0.0001496883,0.000001663134],"about_ca_system_candidate":false,"about_ca_system_consensus":false,"about_ca_system_score_codex":0.0001317976,"about_ca_system_score_gemma":0.00006933425,"about_ca_topic_candidate":false,"about_ca_topic_consensus":false,"about_ca_topic_score_codex":0.0001799524,"about_ca_topic_score_gemma":0.0001364421,"domain_scores_codex":[0.9982099,0.0002316191,0.0004058043,0.0004316632,0.0004311425,0.0002898489],"domain_scores_gemma":[0.9992461,0.00003799975,0.0001627833,0.0002889291,0.0001778331,0.0000863384],"domain_codex":null,"domain_gemma":null,"domain_candidate":null,"domain_consensus":null,"study_design_codex":"bench_or_experimental","study_design_gemma":"bench_or_experimental","study_design_scores_codex":[0.00007618451,0.0001137831,0.007460983,0.00004066357,0.00002572765,7.047605e-7,0.0001822474,0.00002101112,0.9849962,0.000008810803,0.005225443,0.001848256],"study_design_scores_gemma":[0.001172986,0.000099633,0.005612064,0.00004595066,0.00003067863,0.000005776998,0.00001866096,0.00005157378,0.9843289,0.00004940945,0.008379463,0.0002049224],"study_design_candidate":"bench_or_experimental","study_design_consensus":"bench_or_experimental","genre_codex":"empirical","genre_gemma":"empirical","genre_scores_codex":[0.9956951,0.002044979,0.0004377713,0.00086065,0.0001308441,0.0004788486,0.0001344492,0.00001573035,0.0002016652],"genre_scores_gemma":[0.996407,0.0002636183,0.0001292089,0.00005177394,0.0001998912,0.00003585582,0.0002602913,0.00003750788,0.002614906],"genre_candidate":"empirical","genre_consensus":"empirical","teacher_disagreement_score":0.00315402,"threshold_uncertainty_score":0.7471732,"prediction_status":"machine_predicted_unvalidated"},"machine_scores":{"provisional":true,"baseline":true,"maturity_gate_passed":false,"score_opus":0.003012906098936621,"score_gpt":0.225706606686526,"score_spread":0.2226937005875894,"validation_status":"score_only:v0-immature-baseline","note":"Baseline scores from an immature model (maturity gate not passed). Scores rank; they never assert a category."}}